Olive (Olea europaea) Leaf Extract Induces Apoptosis and MonocyteMacrophage Differentiation in Human Chronic Myelogenous Leukemia K562 Cells: Insight into the Underlying Mechanism
المؤلفون المشاركون
Samet, Imen
Jlaiel, Lobna
Sayadi, Sami
Isoda, Hiroko
Han, Junkyu
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-06
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Differentiation therapy is an attractive approach aiming at reversing malignancy and reactivating endogenous differentiation programs in cancer cells.
Olive leaf extract, known for its antioxidant activity, has been demonstrated to induce apoptosis in several cancer cells.
However, its differentiation inducing properties and the mechanisms involved are still poorly understood.
In this study, we investigated the effect of Chemlali Olive Leaf Extract (COLE) for its potential differentiation inducing effect on multipotent leukemia K562 cells.
Results showed that COLE inhibits K562 cells proliferation and arrests the cell cycle at G0/G1, and then at G2/M phase over treatment time.
Further analysis revealed that COLE induces apoptosis and differentiation of K562 cells toward the monocyte lineage.
Microarray analysis was conducted to investigate the underlying mechanism of COLE differentiation inducing effect.
The differentially expressed genes such as IFI16, EGR1, NFYA, FOXP1, CXCL2, CXCL3, and CXCL8 confirmed the commitment of K562 cells to the monocyte/macrophage lineage.
Thus our results provide evidence that, in addition to apoptosis, induction of differentiation is one of the possible therapeutic effects of olive leaf in cancer cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Samet, Imen& Han, Junkyu& Jlaiel, Lobna& Sayadi, Sami& Isoda, Hiroko. 2014. Olive (Olea europaea) Leaf Extract Induces Apoptosis and MonocyteMacrophage Differentiation in Human Chronic Myelogenous Leukemia K562 Cells: Insight into the Underlying Mechanism. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1047167
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Samet, Imen…[et al.]. Olive (Olea europaea) Leaf Extract Induces Apoptosis and MonocyteMacrophage Differentiation in Human Chronic Myelogenous Leukemia K562 Cells: Insight into the Underlying Mechanism. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1047167
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Samet, Imen& Han, Junkyu& Jlaiel, Lobna& Sayadi, Sami& Isoda, Hiroko. Olive (Olea europaea) Leaf Extract Induces Apoptosis and MonocyteMacrophage Differentiation in Human Chronic Myelogenous Leukemia K562 Cells: Insight into the Underlying Mechanism. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1047167
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047167
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر