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Olive (Olea europaea) Leaf Extract Induces Apoptosis and MonocyteMacrophage Differentiation in Human Chronic Myelogenous Leukemia K562 Cells: Insight into the Underlying Mechanism
Joint Authors
Samet, Imen
Jlaiel, Lobna
Sayadi, Sami
Isoda, Hiroko
Han, Junkyu
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-06
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Differentiation therapy is an attractive approach aiming at reversing malignancy and reactivating endogenous differentiation programs in cancer cells.
Olive leaf extract, known for its antioxidant activity, has been demonstrated to induce apoptosis in several cancer cells.
However, its differentiation inducing properties and the mechanisms involved are still poorly understood.
In this study, we investigated the effect of Chemlali Olive Leaf Extract (COLE) for its potential differentiation inducing effect on multipotent leukemia K562 cells.
Results showed that COLE inhibits K562 cells proliferation and arrests the cell cycle at G0/G1, and then at G2/M phase over treatment time.
Further analysis revealed that COLE induces apoptosis and differentiation of K562 cells toward the monocyte lineage.
Microarray analysis was conducted to investigate the underlying mechanism of COLE differentiation inducing effect.
The differentially expressed genes such as IFI16, EGR1, NFYA, FOXP1, CXCL2, CXCL3, and CXCL8 confirmed the commitment of K562 cells to the monocyte/macrophage lineage.
Thus our results provide evidence that, in addition to apoptosis, induction of differentiation is one of the possible therapeutic effects of olive leaf in cancer cells.
American Psychological Association (APA)
Samet, Imen& Han, Junkyu& Jlaiel, Lobna& Sayadi, Sami& Isoda, Hiroko. 2014. Olive (Olea europaea) Leaf Extract Induces Apoptosis and MonocyteMacrophage Differentiation in Human Chronic Myelogenous Leukemia K562 Cells: Insight into the Underlying Mechanism. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1047167
Modern Language Association (MLA)
Samet, Imen…[et al.]. Olive (Olea europaea) Leaf Extract Induces Apoptosis and MonocyteMacrophage Differentiation in Human Chronic Myelogenous Leukemia K562 Cells: Insight into the Underlying Mechanism. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1047167
American Medical Association (AMA)
Samet, Imen& Han, Junkyu& Jlaiel, Lobna& Sayadi, Sami& Isoda, Hiroko. Olive (Olea europaea) Leaf Extract Induces Apoptosis and MonocyteMacrophage Differentiation in Human Chronic Myelogenous Leukemia K562 Cells: Insight into the Underlying Mechanism. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1047167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047167