Evidence Suggesting That Obesity Prevention Measures May Improve Prostate Cancer Outcomes Using Data from a Prospective Randomized Trial
المؤلفون المشاركون
Chen, Ming-Hui
Loffredo, Marian
D'Amico, Anthony V.
Chandra, Ravi A.
Zhang, Danjie
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-13
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Purpose.
Increasing body mass index (BMI) is associated with higher risk prostate cancer (PC) at presentation.
Whether increasing BMI also prompts earlier salvage androgen suppression therapy (sAST) is unknown.
Materials and Methods.
Between 1995 and 2001, 206 men with unfavorable risk PC were treated with radiation therapy (RT) or RT and six months of androgen suppression therapy in a randomized controlled trial (RCT).
108 sustained PSA failure; 51 received sAST for PSA approaching 10 ng/mL; 49 with BMI data comprised the study cohort.
A multivariable Cox regression analysis identified pretreatment factors associated with earlier sAST receipt.
Results.
Increasing BMI prompted earlier sAST (median years: 3.7 for overweight/obese, 6.9 for normal weight; adjusted hazard ratio (AHR): 1.11; 95% CI: 1.04, 1.18; P=0.002) as did high versus other risk PC (median: 3.2 versus 5.2 years; AHR: 2.01; 95% CI: 1.05, 3.83; P=0.03).
Increasing median time to sAST was observed for overweight/obese men with high versus other risk PC and for normal-weight men with any risk PC being 2.3, 4.6, and 6.9 years, respectively (P<0.001 for trend).
Conclusion.
Increasing BMI was associated with earlier sAST.
A RCT evaluating whether BMI reduction delays or eliminates need for sAST is warranted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chandra, Ravi A.& Chen, Ming-Hui& Zhang, Danjie& Loffredo, Marian& D'Amico, Anthony V.. 2014. Evidence Suggesting That Obesity Prevention Measures May Improve Prostate Cancer Outcomes Using Data from a Prospective Randomized Trial. Prostate Cancer،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047189
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chandra, Ravi A.…[et al.]. Evidence Suggesting That Obesity Prevention Measures May Improve Prostate Cancer Outcomes Using Data from a Prospective Randomized Trial. Prostate Cancer No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1047189
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chandra, Ravi A.& Chen, Ming-Hui& Zhang, Danjie& Loffredo, Marian& D'Amico, Anthony V.. Evidence Suggesting That Obesity Prevention Measures May Improve Prostate Cancer Outcomes Using Data from a Prospective Randomized Trial. Prostate Cancer. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047189
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047189
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر