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Evidence Suggesting That Obesity Prevention Measures May Improve Prostate Cancer Outcomes Using Data from a Prospective Randomized Trial
Joint Authors
Chen, Ming-Hui
Loffredo, Marian
D'Amico, Anthony V.
Chandra, Ravi A.
Zhang, Danjie
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
Increasing body mass index (BMI) is associated with higher risk prostate cancer (PC) at presentation.
Whether increasing BMI also prompts earlier salvage androgen suppression therapy (sAST) is unknown.
Materials and Methods.
Between 1995 and 2001, 206 men with unfavorable risk PC were treated with radiation therapy (RT) or RT and six months of androgen suppression therapy in a randomized controlled trial (RCT).
108 sustained PSA failure; 51 received sAST for PSA approaching 10 ng/mL; 49 with BMI data comprised the study cohort.
A multivariable Cox regression analysis identified pretreatment factors associated with earlier sAST receipt.
Results.
Increasing BMI prompted earlier sAST (median years: 3.7 for overweight/obese, 6.9 for normal weight; adjusted hazard ratio (AHR): 1.11; 95% CI: 1.04, 1.18; P=0.002) as did high versus other risk PC (median: 3.2 versus 5.2 years; AHR: 2.01; 95% CI: 1.05, 3.83; P=0.03).
Increasing median time to sAST was observed for overweight/obese men with high versus other risk PC and for normal-weight men with any risk PC being 2.3, 4.6, and 6.9 years, respectively (P<0.001 for trend).
Conclusion.
Increasing BMI was associated with earlier sAST.
A RCT evaluating whether BMI reduction delays or eliminates need for sAST is warranted.
American Psychological Association (APA)
Chandra, Ravi A.& Chen, Ming-Hui& Zhang, Danjie& Loffredo, Marian& D'Amico, Anthony V.. 2014. Evidence Suggesting That Obesity Prevention Measures May Improve Prostate Cancer Outcomes Using Data from a Prospective Randomized Trial. Prostate Cancer،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047189
Modern Language Association (MLA)
Chandra, Ravi A.…[et al.]. Evidence Suggesting That Obesity Prevention Measures May Improve Prostate Cancer Outcomes Using Data from a Prospective Randomized Trial. Prostate Cancer No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1047189
American Medical Association (AMA)
Chandra, Ravi A.& Chen, Ming-Hui& Zhang, Danjie& Loffredo, Marian& D'Amico, Anthony V.. Evidence Suggesting That Obesity Prevention Measures May Improve Prostate Cancer Outcomes Using Data from a Prospective Randomized Trial. Prostate Cancer. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047189