Influence of Hypertension on Neurocognitive Domains in Nondemented Parkinson’s Disease Patients
المؤلفون المشاركون
Jacobson, Charles E.
Okun, Michael S.
Jones, Jacob D.
Murphy, Martina
Price, Catherine
Bowers, Dawn
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
Health comorbidities, particularly cardiovascular risk factors, are well known to pose risks for cognitive decline in older adults.
To date, little attention has focused on the impact of these comorbidities on Parkinson’s disease (PD).
This study examined the prevalence and contribution of comorbidities on cognitive status in PD patients, above and beyond the effects of disease severity.
Methods.
A cross sectional design was used, including neuropsychological data on 341 PD patients without severe cognitive decline.
Comorbidity data were collected via medical chart review.
Data were analyzed using a series of multiple hierarchical regressions, controlling for PD-related disease variables.
Results.
Overall sample characteristics are 69% male, disease duration 9.7 years, Unified Parkinson’s Disease Rating Scale 26.4, and age 64.7 years.
Hypercholesterolemia (41.6%), hypertension (38.1%), and hypotension (30.2%) were the most reported comorbidities.
The presence of hypertension significantly contributed to domains of executive function and verbal memory.
The cooccurrence of orthostatic hypotension moderated the relationship between hypertension and executive function.
Conclusions.
This study on a large cohort of PD patients provides evidence for a detrimental influence of health comorbidities, particularly hypertension, on cognitive domains that have traditionally been conceptualized as being frontally and/or temporally mediated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jones, Jacob D.& Jacobson, Charles E.& Murphy, Martina& Price, Catherine& Okun, Michael S.& Bowers, Dawn. 2014. Influence of Hypertension on Neurocognitive Domains in Nondemented Parkinson’s Disease Patients. Parkinson’s Disease،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047212
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jones, Jacob D.…[et al.]. Influence of Hypertension on Neurocognitive Domains in Nondemented Parkinson’s Disease Patients. Parkinson’s Disease No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1047212
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jones, Jacob D.& Jacobson, Charles E.& Murphy, Martina& Price, Catherine& Okun, Michael S.& Bowers, Dawn. Influence of Hypertension on Neurocognitive Domains in Nondemented Parkinson’s Disease Patients. Parkinson’s Disease. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047212
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047212
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر