Influence of Hypertension on Neurocognitive Domains in Nondemented Parkinson’s Disease Patients
Joint Authors
Jacobson, Charles E.
Okun, Michael S.
Jones, Jacob D.
Murphy, Martina
Price, Catherine
Bowers, Dawn
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
Health comorbidities, particularly cardiovascular risk factors, are well known to pose risks for cognitive decline in older adults.
To date, little attention has focused on the impact of these comorbidities on Parkinson’s disease (PD).
This study examined the prevalence and contribution of comorbidities on cognitive status in PD patients, above and beyond the effects of disease severity.
Methods.
A cross sectional design was used, including neuropsychological data on 341 PD patients without severe cognitive decline.
Comorbidity data were collected via medical chart review.
Data were analyzed using a series of multiple hierarchical regressions, controlling for PD-related disease variables.
Results.
Overall sample characteristics are 69% male, disease duration 9.7 years, Unified Parkinson’s Disease Rating Scale 26.4, and age 64.7 years.
Hypercholesterolemia (41.6%), hypertension (38.1%), and hypotension (30.2%) were the most reported comorbidities.
The presence of hypertension significantly contributed to domains of executive function and verbal memory.
The cooccurrence of orthostatic hypotension moderated the relationship between hypertension and executive function.
Conclusions.
This study on a large cohort of PD patients provides evidence for a detrimental influence of health comorbidities, particularly hypertension, on cognitive domains that have traditionally been conceptualized as being frontally and/or temporally mediated.
American Psychological Association (APA)
Jones, Jacob D.& Jacobson, Charles E.& Murphy, Martina& Price, Catherine& Okun, Michael S.& Bowers, Dawn. 2014. Influence of Hypertension on Neurocognitive Domains in Nondemented Parkinson’s Disease Patients. Parkinson’s Disease،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047212
Modern Language Association (MLA)
Jones, Jacob D.…[et al.]. Influence of Hypertension on Neurocognitive Domains in Nondemented Parkinson’s Disease Patients. Parkinson’s Disease No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1047212
American Medical Association (AMA)
Jones, Jacob D.& Jacobson, Charles E.& Murphy, Martina& Price, Catherine& Okun, Michael S.& Bowers, Dawn. Influence of Hypertension on Neurocognitive Domains in Nondemented Parkinson’s Disease Patients. Parkinson’s Disease. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047212
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047212