Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat
المؤلفون المشاركون
Subramanian, Thyagarajan
Vo, Quynh
Gilmour, Timothy P.
Venkiteswaran, Kala
Fang, Jidong
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-25
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Sleep pattern disruption, specifically REM sleep behavior disorder (RBD), is a major nonmotor cause of disability in PD.
Understanding the pathophysiology of these sleep pattern disturbances is critical to find effective treatments.
24-hour polysomnography (PSG), the gold standard for sleep studies, has never been used to test sleep dysfunction in the standard 6-OHDA lesioned hemiparkinsonian (HP) rat PD model.
In this study, we recorded 24-hour PSG from normal and HP rats.
Recordings were scored into wake, rapid eye movement (REM), and non-REM (NREM).
We then examined EEG to identify REM periods and EMG to check muscle activity during REM.
Normal rats showed higher wakefulness (70–80%) during the dark phase and lower wakefulness (20%) during the light phase.
HP rats showed 30–50% sleep in both phases, less modulation and synchronization to the light schedule ( P < 0.0001 ) , and more long run lengths of wakefulness ( P < 0.05 ) .
HP rats also had more REM epochs with muscle activity than control rats ( P < 0.05 ) .
Our findings that the sleep architecture in the HP rat resembles that of PD patients demonstrate the value of this model in studying the pathophysiological basis of PD sleep disturbances and preclinical therapeutics for PD related sleep disorders including RBD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vo, Quynh& Gilmour, Timothy P.& Venkiteswaran, Kala& Fang, Jidong& Subramanian, Thyagarajan. 2014. Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat. Parkinson’s Disease،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047225
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vo, Quynh…[et al.]. Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat. Parkinson’s Disease No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1047225
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vo, Quynh& Gilmour, Timothy P.& Venkiteswaran, Kala& Fang, Jidong& Subramanian, Thyagarajan. Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat. Parkinson’s Disease. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047225
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047225
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر