Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat
Joint Authors
Subramanian, Thyagarajan
Vo, Quynh
Gilmour, Timothy P.
Venkiteswaran, Kala
Fang, Jidong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sleep pattern disruption, specifically REM sleep behavior disorder (RBD), is a major nonmotor cause of disability in PD.
Understanding the pathophysiology of these sleep pattern disturbances is critical to find effective treatments.
24-hour polysomnography (PSG), the gold standard for sleep studies, has never been used to test sleep dysfunction in the standard 6-OHDA lesioned hemiparkinsonian (HP) rat PD model.
In this study, we recorded 24-hour PSG from normal and HP rats.
Recordings were scored into wake, rapid eye movement (REM), and non-REM (NREM).
We then examined EEG to identify REM periods and EMG to check muscle activity during REM.
Normal rats showed higher wakefulness (70–80%) during the dark phase and lower wakefulness (20%) during the light phase.
HP rats showed 30–50% sleep in both phases, less modulation and synchronization to the light schedule ( P < 0.0001 ) , and more long run lengths of wakefulness ( P < 0.05 ) .
HP rats also had more REM epochs with muscle activity than control rats ( P < 0.05 ) .
Our findings that the sleep architecture in the HP rat resembles that of PD patients demonstrate the value of this model in studying the pathophysiological basis of PD sleep disturbances and preclinical therapeutics for PD related sleep disorders including RBD.
American Psychological Association (APA)
Vo, Quynh& Gilmour, Timothy P.& Venkiteswaran, Kala& Fang, Jidong& Subramanian, Thyagarajan. 2014. Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat. Parkinson’s Disease،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047225
Modern Language Association (MLA)
Vo, Quynh…[et al.]. Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat. Parkinson’s Disease No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1047225
American Medical Association (AMA)
Vo, Quynh& Gilmour, Timothy P.& Venkiteswaran, Kala& Fang, Jidong& Subramanian, Thyagarajan. Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat. Parkinson’s Disease. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047225
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047225