Cognitive Status Correlates with CXCL10IP-10 Levels in Parkinson’s Disease
المؤلفون المشاركون
Vieira, Érica Leandro Marciano
Barbosa, Izabela Guimarães
Rocha, Natália Pessoa
Scalzo, Paula Luciana
Souza, Mariana Soares
Morato, Isabela Boechat
Christo, Paulo Pereira
Reis, Helton José
Teixeira, Antonio Lucio
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Cognitive impairment and depressive symptoms are of great interest in Parkinson’s disease (PD), since they are very common and lead to increased disability with poor quality of life.
Inflammatory mechanisms have been implicated in PD and its nonmotor symptoms.
In the current pilot study, we aimed to evaluate plasma levels of chemokines in PD patients and to analyze the putative association of chemokines with depressive symptoms and cognitive performance.
We hypothesized that higher chemokines levels are associated with worse cognitive performance and increased depressive symptoms in PD.
For this purpose, 40 PD patients and 25 age- and gender-matched controls were subjected to a clinical evaluation including cognitive and mood tests.
Peripheral blood was drawn and plasma levels of CCL2/MCP-1, CCL11/eotaxin, CCL24/eotaxin-2, and CXCL10/IP-10 were measured by enzyme-linked immunosorbent assay.
PD patients and control individuals presented comparable plasma concentrations of all the evaluated chemokines.
In PD patients, CXCL10/IP-10 plasma levels correlated positively with Hoehn and Yahr staging scale.
In addition, the higher CXCL10/IP-10 levels, the worse performance on cognitive tests.
Although there was no significant difference between PD patients and control individuals regarding chemokines levels, our preliminary results showed that CXCL10/IP-10 may be associated with cognitive status in PD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rocha, Natália Pessoa& Scalzo, Paula Luciana& Barbosa, Izabela Guimarães& Souza, Mariana Soares& Morato, Isabela Boechat& Vieira, Érica Leandro Marciano…[et al.]. 2014. Cognitive Status Correlates with CXCL10IP-10 Levels in Parkinson’s Disease. Parkinson’s Disease،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047232
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rocha, Natália Pessoa…[et al.]. Cognitive Status Correlates with CXCL10IP-10 Levels in Parkinson’s Disease. Parkinson’s Disease No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1047232
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rocha, Natália Pessoa& Scalzo, Paula Luciana& Barbosa, Izabela Guimarães& Souza, Mariana Soares& Morato, Isabela Boechat& Vieira, Érica Leandro Marciano…[et al.]. Cognitive Status Correlates with CXCL10IP-10 Levels in Parkinson’s Disease. Parkinson’s Disease. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047232
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047232
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر