Cognitive Status Correlates with CXCL10IP-10 Levels in Parkinson’s Disease
Joint Authors
Vieira, Érica Leandro Marciano
Barbosa, Izabela Guimarães
Rocha, Natália Pessoa
Scalzo, Paula Luciana
Souza, Mariana Soares
Morato, Isabela Boechat
Christo, Paulo Pereira
Reis, Helton José
Teixeira, Antonio Lucio
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cognitive impairment and depressive symptoms are of great interest in Parkinson’s disease (PD), since they are very common and lead to increased disability with poor quality of life.
Inflammatory mechanisms have been implicated in PD and its nonmotor symptoms.
In the current pilot study, we aimed to evaluate plasma levels of chemokines in PD patients and to analyze the putative association of chemokines with depressive symptoms and cognitive performance.
We hypothesized that higher chemokines levels are associated with worse cognitive performance and increased depressive symptoms in PD.
For this purpose, 40 PD patients and 25 age- and gender-matched controls were subjected to a clinical evaluation including cognitive and mood tests.
Peripheral blood was drawn and plasma levels of CCL2/MCP-1, CCL11/eotaxin, CCL24/eotaxin-2, and CXCL10/IP-10 were measured by enzyme-linked immunosorbent assay.
PD patients and control individuals presented comparable plasma concentrations of all the evaluated chemokines.
In PD patients, CXCL10/IP-10 plasma levels correlated positively with Hoehn and Yahr staging scale.
In addition, the higher CXCL10/IP-10 levels, the worse performance on cognitive tests.
Although there was no significant difference between PD patients and control individuals regarding chemokines levels, our preliminary results showed that CXCL10/IP-10 may be associated with cognitive status in PD.
American Psychological Association (APA)
Rocha, Natália Pessoa& Scalzo, Paula Luciana& Barbosa, Izabela Guimarães& Souza, Mariana Soares& Morato, Isabela Boechat& Vieira, Érica Leandro Marciano…[et al.]. 2014. Cognitive Status Correlates with CXCL10IP-10 Levels in Parkinson’s Disease. Parkinson’s Disease،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047232
Modern Language Association (MLA)
Rocha, Natália Pessoa…[et al.]. Cognitive Status Correlates with CXCL10IP-10 Levels in Parkinson’s Disease. Parkinson’s Disease No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1047232
American Medical Association (AMA)
Rocha, Natália Pessoa& Scalzo, Paula Luciana& Barbosa, Izabela Guimarães& Souza, Mariana Soares& Morato, Isabela Boechat& Vieira, Érica Leandro Marciano…[et al.]. Cognitive Status Correlates with CXCL10IP-10 Levels in Parkinson’s Disease. Parkinson’s Disease. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047232
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047232