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TRPV1 Activation Attenuates High-Salt Diet-Induced Cardiac Hypertrophy and Fibrosis through PPAR-δ Upregulation
المؤلفون المشاركون
Gao, Feng
Liang, Yi
Wang, Xiang
Lu, Zongshi
Li, Li
Zhu, Shanjun
Liu, Daoyan
Zhu, Zhiming
Yan, Zhencheng
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-24
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
High-salt diet-induced cardiac hypertrophy and fibrosis are associated with increased reactive oxygen species production.
Transient receptor potential vanilloid type 1 (TRPV1), a specific receptor for capsaicin, exerts a protective role in cardiac remodeling that resulted from myocardial infarction, and peroxisome proliferation-activated receptors δ (PPAR-δ) play an important role in metabolic myocardium remodeling.
However, it remains unknown whether activation of TRPV1 could alleviate cardiac hypertrophy and fibrosis and the effect of cross-talk between TRPV1 and PPAR-δ on suppressing high-salt diet-generated oxidative stress.
In this study, high-salt diet-induced cardiac hypertrophy and fibrosis are characterized by significant enhancement of HW/BW%, LVEDD, and LVESD, decreased FS and EF, and increased collagen deposition.
These alterations were associated with downregulation of PPAR-δ, UCP2 expression, upregulation of iNOS production, and increased oxidative/nitrotyrosine stress.
These adverse effects of long-term high-salt diet were attenuated by chronic treatment with capsaicin.
However, this effect of capsaicin was absent in TRPV1−/− mice on a high-salt diet.
Our finding suggests that chronic dietary capsaicin consumption attenuates long-term high-salt diet-induced cardiac hypertrophy and fibrosis.
This benefit effect is likely to be caused by TRPV1 mediated upregulation of PPAR-δ expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gao, Feng& Liang, Yi& Wang, Xiang& Lu, Zongshi& Li, Li& Zhu, Shanjun…[et al.]. 2014. TRPV1 Activation Attenuates High-Salt Diet-Induced Cardiac Hypertrophy and Fibrosis through PPAR-δ Upregulation. PPAR Research،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1047279
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gao, Feng…[et al.]. TRPV1 Activation Attenuates High-Salt Diet-Induced Cardiac Hypertrophy and Fibrosis through PPAR-δ Upregulation. PPAR Research No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1047279
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gao, Feng& Liang, Yi& Wang, Xiang& Lu, Zongshi& Li, Li& Zhu, Shanjun…[et al.]. TRPV1 Activation Attenuates High-Salt Diet-Induced Cardiac Hypertrophy and Fibrosis through PPAR-δ Upregulation. PPAR Research. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1047279
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047279
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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