TRPV1 Activation Attenuates High-Salt Diet-Induced Cardiac Hypertrophy and Fibrosis through PPAR-δ Upregulation
Joint Authors
Gao, Feng
Liang, Yi
Wang, Xiang
Lu, Zongshi
Li, Li
Zhu, Shanjun
Liu, Daoyan
Zhu, Zhiming
Yan, Zhencheng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
High-salt diet-induced cardiac hypertrophy and fibrosis are associated with increased reactive oxygen species production.
Transient receptor potential vanilloid type 1 (TRPV1), a specific receptor for capsaicin, exerts a protective role in cardiac remodeling that resulted from myocardial infarction, and peroxisome proliferation-activated receptors δ (PPAR-δ) play an important role in metabolic myocardium remodeling.
However, it remains unknown whether activation of TRPV1 could alleviate cardiac hypertrophy and fibrosis and the effect of cross-talk between TRPV1 and PPAR-δ on suppressing high-salt diet-generated oxidative stress.
In this study, high-salt diet-induced cardiac hypertrophy and fibrosis are characterized by significant enhancement of HW/BW%, LVEDD, and LVESD, decreased FS and EF, and increased collagen deposition.
These alterations were associated with downregulation of PPAR-δ, UCP2 expression, upregulation of iNOS production, and increased oxidative/nitrotyrosine stress.
These adverse effects of long-term high-salt diet were attenuated by chronic treatment with capsaicin.
However, this effect of capsaicin was absent in TRPV1−/− mice on a high-salt diet.
Our finding suggests that chronic dietary capsaicin consumption attenuates long-term high-salt diet-induced cardiac hypertrophy and fibrosis.
This benefit effect is likely to be caused by TRPV1 mediated upregulation of PPAR-δ expression.
American Psychological Association (APA)
Gao, Feng& Liang, Yi& Wang, Xiang& Lu, Zongshi& Li, Li& Zhu, Shanjun…[et al.]. 2014. TRPV1 Activation Attenuates High-Salt Diet-Induced Cardiac Hypertrophy and Fibrosis through PPAR-δ Upregulation. PPAR Research،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1047279
Modern Language Association (MLA)
Gao, Feng…[et al.]. TRPV1 Activation Attenuates High-Salt Diet-Induced Cardiac Hypertrophy and Fibrosis through PPAR-δ Upregulation. PPAR Research No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1047279
American Medical Association (AMA)
Gao, Feng& Liang, Yi& Wang, Xiang& Lu, Zongshi& Li, Li& Zhu, Shanjun…[et al.]. TRPV1 Activation Attenuates High-Salt Diet-Induced Cardiac Hypertrophy and Fibrosis through PPAR-δ Upregulation. PPAR Research. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1047279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047279