Osteosarcoma in Pediatric Patients and Young Adults: A Single Institution Retrospective Review of Presentation, Therapy, and Outcome
المؤلفون المشاركون
Bui, Marilyn M.
Haddox, Candace L.
Han, Gang
Anijar, Leon
Binitie, Odion
Reed, Damon R.
Letson, G. Douglas
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Little is known about how cumulative chemotherapy delivery influences the poorer outcome observed in young adult (YA, 18–40 years) versus pediatric (<18 years) osteosarcoma patients.
Here, we retrospectively examined differences in presentation, therapy, including cumulative chemotherapy dose, and outcome in YA and pediatric patients.
Methods.
We reviewed 111 cases of high-grade osteosarcoma at Moffitt Cancer Center between 1988 and 2012.
Presentation factors, therapies, and survival were compared between YA and pediatric cohorts.
Results.
The cohorts were equivalent with respect to metastatic status, gender, tumor size, tumor site, and histological subtype.
We found that the YA patients tended to have poorer histologic response to neoadjuvant chemotherapy measured by necrosis with 55% and 35% of pediatric versus YA patients responding favorably ( P = 0.06 ).
Only 39% of YA patients achieved the typical pediatric dose of methotrexate, doxorubicin, and cisplatin.
These patients had a 3-year EFS of 76% (CI 53–100%) versus 47% (CI 26–69%; P = 0.09 ) in those who received less chemotherapy.
Conclusion.
Age continues to be a prognostic factor in osteosarcoma.
Our study suggests that presentation factors are not associated with prognosis, while poorer response to chemotherapy and lower cumulative dose of chemotherapy delivered to YA patients may contribute to poorer outcomes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Haddox, Candace L.& Han, Gang& Anijar, Leon& Binitie, Odion& Letson, G. Douglas& Bui, Marilyn M.…[et al.]. 2014. Osteosarcoma in Pediatric Patients and Young Adults: A Single Institution Retrospective Review of Presentation, Therapy, and Outcome. Complexity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047445
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Haddox, Candace L.…[et al.]. Osteosarcoma in Pediatric Patients and Young Adults: A Single Institution Retrospective Review of Presentation, Therapy, and Outcome. Complexity Vol. 2014, no. 2014 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1047445
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Haddox, Candace L.& Han, Gang& Anijar, Leon& Binitie, Odion& Letson, G. Douglas& Bui, Marilyn M.…[et al.]. Osteosarcoma in Pediatric Patients and Young Adults: A Single Institution Retrospective Review of Presentation, Therapy, and Outcome. Complexity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047445
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047445
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر