Osteosarcoma in Pediatric Patients and Young Adults: A Single Institution Retrospective Review of Presentation, Therapy, and Outcome
Joint Authors
Bui, Marilyn M.
Haddox, Candace L.
Han, Gang
Anijar, Leon
Binitie, Odion
Reed, Damon R.
Letson, G. Douglas
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Little is known about how cumulative chemotherapy delivery influences the poorer outcome observed in young adult (YA, 18–40 years) versus pediatric (<18 years) osteosarcoma patients.
Here, we retrospectively examined differences in presentation, therapy, including cumulative chemotherapy dose, and outcome in YA and pediatric patients.
Methods.
We reviewed 111 cases of high-grade osteosarcoma at Moffitt Cancer Center between 1988 and 2012.
Presentation factors, therapies, and survival were compared between YA and pediatric cohorts.
Results.
The cohorts were equivalent with respect to metastatic status, gender, tumor size, tumor site, and histological subtype.
We found that the YA patients tended to have poorer histologic response to neoadjuvant chemotherapy measured by necrosis with 55% and 35% of pediatric versus YA patients responding favorably ( P = 0.06 ).
Only 39% of YA patients achieved the typical pediatric dose of methotrexate, doxorubicin, and cisplatin.
These patients had a 3-year EFS of 76% (CI 53–100%) versus 47% (CI 26–69%; P = 0.09 ) in those who received less chemotherapy.
Conclusion.
Age continues to be a prognostic factor in osteosarcoma.
Our study suggests that presentation factors are not associated with prognosis, while poorer response to chemotherapy and lower cumulative dose of chemotherapy delivered to YA patients may contribute to poorer outcomes.
American Psychological Association (APA)
Haddox, Candace L.& Han, Gang& Anijar, Leon& Binitie, Odion& Letson, G. Douglas& Bui, Marilyn M.…[et al.]. 2014. Osteosarcoma in Pediatric Patients and Young Adults: A Single Institution Retrospective Review of Presentation, Therapy, and Outcome. Complexity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047445
Modern Language Association (MLA)
Haddox, Candace L.…[et al.]. Osteosarcoma in Pediatric Patients and Young Adults: A Single Institution Retrospective Review of Presentation, Therapy, and Outcome. Complexity Vol. 2014, no. 2014 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1047445
American Medical Association (AMA)
Haddox, Candace L.& Han, Gang& Anijar, Leon& Binitie, Odion& Letson, G. Douglas& Bui, Marilyn M.…[et al.]. Osteosarcoma in Pediatric Patients and Young Adults: A Single Institution Retrospective Review of Presentation, Therapy, and Outcome. Complexity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047445
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047445