Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma
المؤلفون المشاركون
Thampi, Sheila
Boscardin, W. John
Goldsby, Robert
Matthay, Katherine K.
DuBois, Steven G.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Extraskeletal osteosarcoma (ESOS) is a rare subtype of osteosarcoma.
We investigated patient characteristics, overall survival, and prognostic factors in ESOS.
Methods.
We identified cases of high-grade osteosarcoma with known tissue of origin in the Surveillance, Epidemiology, and End Results database from 1973 to 2009.
Demographics were compared using univariate tests.
Overall survival was compared with log-rank tests and multivariate analysis using Cox proportional hazards methods.
Results.
256/4,173 (6%) patients with high-grade osteosarcoma had ESOS.
Patients with ESOS were older, were more likely to have an axial tumor and regional lymph node involvement, and were female.
Multivariate analysis showed ESOS to be favorable after controlling for stage, age, tumor site, gender, and year of diagnosis [hazard ratio 0.75 (95% CI 0.62 to 0.90); p = 0.002 ].
There was an interaction between age and tissue of origin such that older patients with ESOS had superior outcomes compared to older patients with skeletal osteosarcoma.
Adverse prognostic factors in ESOS included metastatic disease, larger tumor size, older age, and axial tumor site.
Conclusion.
Patients with ESOS have distinct clinical features but similar prognostic factors compared to skeletal osteosarcoma.
Older patients with ESOS have superior outcomes compared to older patients with skeletal osteosarcoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Thampi, Sheila& Matthay, Katherine K.& Boscardin, W. John& Goldsby, Robert& DuBois, Steven G.. 2014. Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma. Complexity،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047461
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Thampi, Sheila…[et al.]. Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma. Complexity Vol. 2014, no. 2014 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1047461
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Thampi, Sheila& Matthay, Katherine K.& Boscardin, W. John& Goldsby, Robert& DuBois, Steven G.. Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma. Complexity. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047461
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047461
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر