Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma
Joint Authors
Thampi, Sheila
Boscardin, W. John
Goldsby, Robert
Matthay, Katherine K.
DuBois, Steven G.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Extraskeletal osteosarcoma (ESOS) is a rare subtype of osteosarcoma.
We investigated patient characteristics, overall survival, and prognostic factors in ESOS.
Methods.
We identified cases of high-grade osteosarcoma with known tissue of origin in the Surveillance, Epidemiology, and End Results database from 1973 to 2009.
Demographics were compared using univariate tests.
Overall survival was compared with log-rank tests and multivariate analysis using Cox proportional hazards methods.
Results.
256/4,173 (6%) patients with high-grade osteosarcoma had ESOS.
Patients with ESOS were older, were more likely to have an axial tumor and regional lymph node involvement, and were female.
Multivariate analysis showed ESOS to be favorable after controlling for stage, age, tumor site, gender, and year of diagnosis [hazard ratio 0.75 (95% CI 0.62 to 0.90); p = 0.002 ].
There was an interaction between age and tissue of origin such that older patients with ESOS had superior outcomes compared to older patients with skeletal osteosarcoma.
Adverse prognostic factors in ESOS included metastatic disease, larger tumor size, older age, and axial tumor site.
Conclusion.
Patients with ESOS have distinct clinical features but similar prognostic factors compared to skeletal osteosarcoma.
Older patients with ESOS have superior outcomes compared to older patients with skeletal osteosarcoma.
American Psychological Association (APA)
Thampi, Sheila& Matthay, Katherine K.& Boscardin, W. John& Goldsby, Robert& DuBois, Steven G.. 2014. Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma. Complexity،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047461
Modern Language Association (MLA)
Thampi, Sheila…[et al.]. Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma. Complexity Vol. 2014, no. 2014 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1047461
American Medical Association (AMA)
Thampi, Sheila& Matthay, Katherine K.& Boscardin, W. John& Goldsby, Robert& DuBois, Steven G.. Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma. Complexity. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047461