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Directing Parthenogenetic Stem Cells Differentiate into Adipocytes for Engineering Injectable Adipose Tissue
المؤلفون المشاركون
Yang, Xinyuan
Liu, Wei
Yan, Xingrong
Cui, Jihong
Liu, Wenguang
Sun, Mei
Rao, Yang
Chen, Fulin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-23
دولة النشر
مصر
عدد الصفحات
16
الملخص EN
The selection of appropriate seed cells is crucial for adipose tissue engineering.
Here, we reported the stepwise induction of parthenogenetic embryonic stem cells (pESCs) to differentiate into adipogenic cells and its application in engineering injectable adipose tissue with Pluronic F-127.
pESCs had pluripotent differentiation capacity and could form teratomas that include the three primary germ layers.
Cells that migrated from the embryoid bodies (EBs) were selectively separated and expanded to obtain embryonic mesenchymal stem cells (eMSCs).
The eMSCs exhibited similar cell surface marker expression profiles with bone morrow mesenchymal stem cells (BMSCs) and had multipotent differentiation capacity.
Under the induction of dexamethasone, indomethacin, and insulin, eMSCs could differentiate into adipogenic cells with increased expression of adipose-specific genes and oil droplet depositions within the cytoplasm.
To evaluate their suitability as seed cells for adipose tissue engineering, the CM-Dil labelled adipogenic cells derived from eMSCs were seeded into Pluronic F-127 hydrogel and injected subcutaneously into nude mice.
Four weeks after injection, glistering and semitransparent constructs formed in the subcutaneous site.
Histological observations demonstrated that new adipose tissue was successfully fabricated in the specimen by the labelled cells.
The results of the current study indicated that pESCs have great potential in the fabrication of injectable adipose tissue.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Wei& Yang, Xinyuan& Yan, Xingrong& Cui, Jihong& Liu, Wenguang& Sun, Mei…[et al.]. 2014. Directing Parthenogenetic Stem Cells Differentiate into Adipocytes for Engineering Injectable Adipose Tissue. Stem Cells International،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1047515
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Wei…[et al.]. Directing Parthenogenetic Stem Cells Differentiate into Adipocytes for Engineering Injectable Adipose Tissue. Stem Cells International No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1047515
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Wei& Yang, Xinyuan& Yan, Xingrong& Cui, Jihong& Liu, Wenguang& Sun, Mei…[et al.]. Directing Parthenogenetic Stem Cells Differentiate into Adipocytes for Engineering Injectable Adipose Tissue. Stem Cells International. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1047515
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047515
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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