Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients

المؤلفون المشاركون

Lee, Su-Jae
Huh, Yong-Min
Hong, Yong-Kil
Kong, Byung Ho
Moon, Ju Hyung
Shim, Jin-Kyoung
Lee, Ji-Hyun
Kim, Eui-Hyun
Chang, Jong Hee
Kim, Dong-Seok
Kim, Sun Ho
Kang, Seok-Gu

المصدر

Stem Cells International

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-12-11

دولة النشر

مصر

عدد الصفحات

6

الملخص EN

Cancer stem cells (CSCs) have been reported to be critical in the initiation, maintenance, and progression of cancers.

The expression of stem cell markers, such as podoplanin (PDPN), CD133, and nestin, may have been correlated with malignant progression.

However, the effects of CSCs and stem cell markers on clinical outcomes in cancer patients remain unclear.

In this study, we assessed the prognostic roles of glioma CSCs (gCSCs) isolation and stem cell markers in patients with primary glioblastoma (pGBM).

A cohort of 39 patients with pGBM was separated into two groups, those positive or negative for gCSCs, and the correlation between gCSC and patient survival was evaluated.

We observed significantly different cumulative survival ( P = 0.045 ) when comparing patients positive for gCSCs patients and negative for gCSC.

Among the patients positive for gCSCs, we observed no significant differences in survival between those whose gCSCs were each positive or negative for PDPN, CD133, or nestin.

This study strongly supports the prognostic value of gCSCs isolation on the survival of patients with pGBM.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kong, Byung Ho& Moon, Ju Hyung& Huh, Yong-Min& Shim, Jin-Kyoung& Lee, Ji-Hyun& Kim, Eui-Hyun…[et al.]. 2014. Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients. Stem Cells International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047532

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kong, Byung Ho…[et al.]. Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients. Stem Cells International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1047532

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kong, Byung Ho& Moon, Ju Hyung& Huh, Yong-Min& Shim, Jin-Kyoung& Lee, Ji-Hyun& Kim, Eui-Hyun…[et al.]. Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients. Stem Cells International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047532

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1047532