Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients
Joint Authors
Lee, Su-Jae
Huh, Yong-Min
Hong, Yong-Kil
Kong, Byung Ho
Moon, Ju Hyung
Shim, Jin-Kyoung
Lee, Ji-Hyun
Kim, Eui-Hyun
Chang, Jong Hee
Kim, Dong-Seok
Kim, Sun Ho
Kang, Seok-Gu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-11
Country of Publication
Egypt
No. of Pages
6
Abstract EN
Cancer stem cells (CSCs) have been reported to be critical in the initiation, maintenance, and progression of cancers.
The expression of stem cell markers, such as podoplanin (PDPN), CD133, and nestin, may have been correlated with malignant progression.
However, the effects of CSCs and stem cell markers on clinical outcomes in cancer patients remain unclear.
In this study, we assessed the prognostic roles of glioma CSCs (gCSCs) isolation and stem cell markers in patients with primary glioblastoma (pGBM).
A cohort of 39 patients with pGBM was separated into two groups, those positive or negative for gCSCs, and the correlation between gCSC and patient survival was evaluated.
We observed significantly different cumulative survival ( P = 0.045 ) when comparing patients positive for gCSCs patients and negative for gCSC.
Among the patients positive for gCSCs, we observed no significant differences in survival between those whose gCSCs were each positive or negative for PDPN, CD133, or nestin.
This study strongly supports the prognostic value of gCSCs isolation on the survival of patients with pGBM.
American Psychological Association (APA)
Kong, Byung Ho& Moon, Ju Hyung& Huh, Yong-Min& Shim, Jin-Kyoung& Lee, Ji-Hyun& Kim, Eui-Hyun…[et al.]. 2014. Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients. Stem Cells International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047532
Modern Language Association (MLA)
Kong, Byung Ho…[et al.]. Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients. Stem Cells International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1047532
American Medical Association (AMA)
Kong, Byung Ho& Moon, Ju Hyung& Huh, Yong-Min& Shim, Jin-Kyoung& Lee, Ji-Hyun& Kim, Eui-Hyun…[et al.]. Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients. Stem Cells International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047532
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047532