The Efficacy of Mesenchymal Stem Cell Transplantation in Caustic Esophagus Injury: An Experimental Study
المؤلفون المشاركون
Kantarcioglu, Murat
Caliskan, Bahadir
Demirci, Hakan
Karacalioglu, Ozgur
Kekilli, Murat
Polat, Zulfikar
Gunal, Armagan
Akinci, Melih
Uysal, Cagri
Eksert, Sami
Gurel, Hasan
Celebi, Gurkan
Avcu, Ferit
Ural, Ali Ugur
Bagci, Sait
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-04
دولة النشر
مصر
عدد الصفحات
7
الملخص EN
Introduction.
Ingestion of corrosive substances may lead to stricture formation in esophagus as a late complication.
Full thickness injury seems to exterminate tissue stem cells of esophagus.
Mesenchymal stem cells (MSCs) can differentiate into specific cell lineages and have the capacity of homing in sites of injury.
Aim and Methods.
We aimed to investigate the efficacy of MSC transplantation, on prevention of esophageal damage and stricture formation after caustic esophagus injury in rats.
54 rats were allocated into four groups; 4 rats were sacrificed for MSC production.
Group 1, untreated controls (n: 10).
Group 2, membrane labeled MSCs-treated rats (n: 20).
Group 3, biodistribution of fluorodeoxyglucose labeled MSCs via positron emission tomography (PET) imaging (n: 10).
Group 4, sham operated (n: 10).
Standard caustic esophageal burns were created and MSCs were transplanted 24 hours after.
All rats were sacrificed at the 21st days.
Results.
PET scan images revealed the homing behavior of MSCs to the injury site.
The histopathology damage score was not significantly different from controls.
However, we demonstrated Dil labeled epithelial and muscle cells which were originating from transplanted MSCs.
Conclusion.
MSC transplantation after caustic esophageal injury may be a helpful treatment modality; however, probably repeated infusions are needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kantarcioglu, Murat& Caliskan, Bahadir& Demirci, Hakan& Karacalioglu, Ozgur& Kekilli, Murat& Polat, Zulfikar…[et al.]. 2014. The Efficacy of Mesenchymal Stem Cell Transplantation in Caustic Esophagus Injury: An Experimental Study. Stem Cells International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047539
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kantarcioglu, Murat…[et al.]. The Efficacy of Mesenchymal Stem Cell Transplantation in Caustic Esophagus Injury: An Experimental Study. Stem Cells International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1047539
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kantarcioglu, Murat& Caliskan, Bahadir& Demirci, Hakan& Karacalioglu, Ozgur& Kekilli, Murat& Polat, Zulfikar…[et al.]. The Efficacy of Mesenchymal Stem Cell Transplantation in Caustic Esophagus Injury: An Experimental Study. Stem Cells International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047539
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047539
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر