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Histopathological Findings in Immunohistological Staining of the Granulomatous Tissue Reaction Associated with Tuberculosis
المؤلفون المشاركون
Bahadori, Moslem
Karimi, Shirin
Shamaei, Masoud
Pourabdollah, Mihan
Sadr, Makan
Karbasi, Mehrdad
Kiani, Arda
المصدر
Tuberculosis Research and Treatment
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-05
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Purpose.
The histological diagnosis of Mycobacterium tuberculosis (MTB) remains a diagnostic challenge despite different methods.
Immunohistochemistry (IHC) not only could confirm granulomatous tissue involvement but also can demonstrate MTB antigen immunolocalization.
This study tries to clarify the details of immunohistochemical staining for MTB with pAbBCG.
Materials/Methods.
Twenty-three confirmed TB granulomatous tissue samples were studied by Ziehl-Neelsen and immunohistochemistry (IHC) staining with pAbBCG.
Samples were selected from the archive of the Department of Pathology, National Research Institute of Tuberculosis and Lung Disease, Tehran, Iran.
Results.
IHC staining was positive in all samples, whereas Ziehl-Neelsen was positive in 9 cases out of 23 (39.1%).
Tissue types used were pleural tissue, lymph nodes, and lung tissue.
IHC showed positive coarse granular cytoplasmic and round, fragmented bacillary staining.
In this study, epithelioid cells clearly showed more positive staining at the periphery of the granuloma rather than the center of granuloma.
There is also positive staining in endothelial cells, fibroblasts, plasma cells, lymphocytes, and macrophages outside the granuloma.
Conclusion.
Considering the criteria of positive immunohistochemical staining of TB granulomatous reactions, this stain not only highlights the presence of mycobacterial antigens for tissue diagnosis, but also could morphologically localize its distribution in different cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Karimi, Shirin& Shamaei, Masoud& Pourabdollah, Mihan& Sadr, Makan& Karbasi, Mehrdad& Kiani, Arda…[et al.]. 2014. Histopathological Findings in Immunohistological Staining of the Granulomatous Tissue Reaction Associated with Tuberculosis. Tuberculosis Research and Treatment،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1048075
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Karimi, Shirin…[et al.]. Histopathological Findings in Immunohistological Staining of the Granulomatous Tissue Reaction Associated with Tuberculosis. Tuberculosis Research and Treatment No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1048075
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Karimi, Shirin& Shamaei, Masoud& Pourabdollah, Mihan& Sadr, Makan& Karbasi, Mehrdad& Kiani, Arda…[et al.]. Histopathological Findings in Immunohistological Staining of the Granulomatous Tissue Reaction Associated with Tuberculosis. Tuberculosis Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1048075
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1048075
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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