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Adipose Derived Mesenchymal Stem Cells Efficiently Rescue Carbon Tetrachloride-Induced Acute Liver Failure in Mouse
المؤلفون المشاركون
Deng, Lisi
Liu, Guangze
Wu, Xin
Wang, Yaping
Tong, Minghua
Liu, Bing
Wang, Kuidong
Peng, Yuting
Kong, Xiangping
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Background and Aim.
Adipose derived mesenchymal stem cells (ADMSCs) may be an attractive source for acute and chronic liver injury because they are abundant and easy to obtain.
We aim to investigate the efficacy of ADMSCs transplantation in the acute liver failure (ALF) caused by carbon tetrachloride (CCl4) in mice.
Methods.
ADMSCs were isolated from inguinal fat pads of enhanced green fluorescent protein (EGFP) transgenic mice and their surface markers and differentiation potential were analyzed.
ALF models were established by infusion of CCl4 and divided into two groups: control group; EGFP-ADMSCs transplantation group.
The restoration of biological functions of the livers receiving transplantation was assessed via a variety of approaches such as survival rates, live function parameters, histological localization of EGFP-ADMSCs, and Immunofluorescence analysis.
Results.
ADMSCs were positive for CD105, CD44 but negative for CD45, CD34 and had adipogenic, osteogenic differentiation potential.
The survival rate of transplantation group significantly increased compared to PBS group.
Furthermore, the transplanted cells were well integrated into injured livers and produced albumin, cytokeratin-18.
Conclusion.
Direct transplantation of ADMSCs is an effective treatment for ALF.
The transplanted ADMSCs exhibit the potential to differentiate into hepatocyte-like cells in the injured livers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Deng, Lisi& Liu, Guangze& Wu, Xin& Wang, Yaping& Tong, Minghua& Liu, Bing…[et al.]. 2014. Adipose Derived Mesenchymal Stem Cells Efficiently Rescue Carbon Tetrachloride-Induced Acute Liver Failure in Mouse. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1048301
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Deng, Lisi…[et al.]. Adipose Derived Mesenchymal Stem Cells Efficiently Rescue Carbon Tetrachloride-Induced Acute Liver Failure in Mouse. The Scientific World Journal No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1048301
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Deng, Lisi& Liu, Guangze& Wu, Xin& Wang, Yaping& Tong, Minghua& Liu, Bing…[et al.]. Adipose Derived Mesenchymal Stem Cells Efficiently Rescue Carbon Tetrachloride-Induced Acute Liver Failure in Mouse. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1048301
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1048301
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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