Adipose Derived Mesenchymal Stem Cells Efficiently Rescue Carbon Tetrachloride-Induced Acute Liver Failure in Mouse
Joint Authors
Deng, Lisi
Liu, Guangze
Wu, Xin
Wang, Yaping
Tong, Minghua
Liu, Bing
Wang, Kuidong
Peng, Yuting
Kong, Xiangping
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Background and Aim.
Adipose derived mesenchymal stem cells (ADMSCs) may be an attractive source for acute and chronic liver injury because they are abundant and easy to obtain.
We aim to investigate the efficacy of ADMSCs transplantation in the acute liver failure (ALF) caused by carbon tetrachloride (CCl4) in mice.
Methods.
ADMSCs were isolated from inguinal fat pads of enhanced green fluorescent protein (EGFP) transgenic mice and their surface markers and differentiation potential were analyzed.
ALF models were established by infusion of CCl4 and divided into two groups: control group; EGFP-ADMSCs transplantation group.
The restoration of biological functions of the livers receiving transplantation was assessed via a variety of approaches such as survival rates, live function parameters, histological localization of EGFP-ADMSCs, and Immunofluorescence analysis.
Results.
ADMSCs were positive for CD105, CD44 but negative for CD45, CD34 and had adipogenic, osteogenic differentiation potential.
The survival rate of transplantation group significantly increased compared to PBS group.
Furthermore, the transplanted cells were well integrated into injured livers and produced albumin, cytokeratin-18.
Conclusion.
Direct transplantation of ADMSCs is an effective treatment for ALF.
The transplanted ADMSCs exhibit the potential to differentiate into hepatocyte-like cells in the injured livers.
American Psychological Association (APA)
Deng, Lisi& Liu, Guangze& Wu, Xin& Wang, Yaping& Tong, Minghua& Liu, Bing…[et al.]. 2014. Adipose Derived Mesenchymal Stem Cells Efficiently Rescue Carbon Tetrachloride-Induced Acute Liver Failure in Mouse. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1048301
Modern Language Association (MLA)
Deng, Lisi…[et al.]. Adipose Derived Mesenchymal Stem Cells Efficiently Rescue Carbon Tetrachloride-Induced Acute Liver Failure in Mouse. The Scientific World Journal No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1048301
American Medical Association (AMA)
Deng, Lisi& Liu, Guangze& Wu, Xin& Wang, Yaping& Tong, Minghua& Liu, Bing…[et al.]. Adipose Derived Mesenchymal Stem Cells Efficiently Rescue Carbon Tetrachloride-Induced Acute Liver Failure in Mouse. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1048301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048301