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Diverse Effects of Lead Nitrate on the Proliferation, Differentiation, and Gene Expression of Stem Cells Isolated from a Dental Origin
المؤلفون المشاركون
Abu Kasim, Noor Hayaty
Musa, Sabri
Govindasamy, Vijayendran
Abdullah, Mariam
Rahman, Fazliny Abd.
Gnanasegaran, Nareshwaran
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Lead (Pb2+) exposure continues to be a significant public health problem.
Therefore, it is vital to have a continuous epidemiological dataset for a better understanding of Pb2+ toxicity.
In the present study, we have exposed stem cells isolated from deciduous and permanent teeth, periodontal ligament, and bone marrow to five different types of Pb2+ concentrations (160, 80, 40, 20, and 10 µM) for 24 hours to identify the adverse effects of Pb2+ on the proliferation, differentiation, and gene expression on these cell lines.
We found that Pb2+ treatment altered the morphology and adhesion of the cells in a dose-dependent manner.
There were no significant changes in terms of cell surface phenotypes.
Cells exposed to Pb2+ continued to differentiate into chondrogenesis and adipogenesis, and a severe downregulation was observed in osteogenesis.
Gene expression studies revealed a constant expression of key markers associated with stemness (Oct 4, Rex 1) and DNA repair enzyme markers, but downregulation occurred with some ectoderm and endoderm markers, demonstrating an irregular and untimely differentiation trail.
Our study revealed for the first time that Pb2+ exposure not only affects the phenotypic characteristics but also induces significant alteration in the differentiation and gene expression in the cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abdullah, Mariam& Rahman, Fazliny Abd.& Gnanasegaran, Nareshwaran& Govindasamy, Vijayendran& Abu Kasim, Noor Hayaty& Musa, Sabri. 2014. Diverse Effects of Lead Nitrate on the Proliferation, Differentiation, and Gene Expression of Stem Cells Isolated from a Dental Origin. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1048826
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abdullah, Mariam…[et al.]. Diverse Effects of Lead Nitrate on the Proliferation, Differentiation, and Gene Expression of Stem Cells Isolated from a Dental Origin. The Scientific World Journal No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1048826
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abdullah, Mariam& Rahman, Fazliny Abd.& Gnanasegaran, Nareshwaran& Govindasamy, Vijayendran& Abu Kasim, Noor Hayaty& Musa, Sabri. Diverse Effects of Lead Nitrate on the Proliferation, Differentiation, and Gene Expression of Stem Cells Isolated from a Dental Origin. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1048826
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1048826
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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