Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves

الملخص EN

Antimetastatic and anti-inflammatory activities of Ocimum sanctum essential oil (OSEO) have been assessed in this study.

OSEO at the concentration of 250 μg/mL and above showed a significant (P*<0.05) decrease in the number of migrated cancer cells.

In addition, OSEO at concentration of 250 μg/mL and above suppressed MMP-9 activity in lipopolysaccharide (LPS) induced inflammatory cells.

A dose-dependent downregulation of MMP-9 expression was observed with the treatment of OSEO compared to the control.

Our findings indicate that OSEO has both antimetastatic and anti-inflammatory potentials, advocating further investigation for clinical applications in the treatment of inflammation associated cancer.