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Modulating the p66shc Signaling Pathway with Protocatechuic Acid Protects the Intestine from Ischemia-Reperfusion Injury and Alleviates Secondary Liver Damage
المؤلفون المشاركون
Yao, Jihong
Ma, Lingfei
Wang, Guangzhi
Chen, Zhao
Li, Zhenlu
Zhao, Haidong
Wang, Shu
Ma, Zhenhai
Chang, Hong
Tian, Xiaofeng
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-15
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Intestinal ischemia-reperfusion (I/R) injury is a serious clinical pathophysiological process that may result in acute local intestine and remote liver injury.
Protocatechuic acid (PCA), which has been widely studied as a polyphenolic compound, induces expression of antioxidative genes that combat oxidative stress and cell apoptosis.
In this study, we investigated the effect of PCA pretreatment for protecting intestinal I/R-induced local intestine and remote liver injury in mice.
Intestinal I/R was established by superior mesenteric artery occlusion for 45 min followed by reperfusion for 90 min.
After the reperfusion period, PCA pretreatment markedly alleviated intestine and liver injury induced by intestinal I/R as indicated by histological alterations, decreases in serological damage parameters and nuclear factor-kappa B and phospho-foxo3a protein expression levels, and increases in glutathione, glutathione peroxidase, manganese superoxide dismutase protein expression, and Bcl-xL protein expression in the intestine and liver.
These parameters were accompanied by PCA-induced adaptor protein p66shc suppression.
These results suggest that PCA has a significant protective effect in the intestine and liver following injury induced by intestinal I/R.
The protective effect of PCA may be attributed to the suppression of p66shc and the regulation of p66shc-related antioxidative and antiapoptotic factors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Lingfei& Wang, Guangzhi& Chen, Zhao& Li, Zhenlu& Yao, Jihong& Zhao, Haidong…[et al.]. 2014. Modulating the p66shc Signaling Pathway with Protocatechuic Acid Protects the Intestine from Ischemia-Reperfusion Injury and Alleviates Secondary Liver Damage. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1049420
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Lingfei…[et al.]. Modulating the p66shc Signaling Pathway with Protocatechuic Acid Protects the Intestine from Ischemia-Reperfusion Injury and Alleviates Secondary Liver Damage. The Scientific World Journal No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1049420
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Lingfei& Wang, Guangzhi& Chen, Zhao& Li, Zhenlu& Yao, Jihong& Zhao, Haidong…[et al.]. Modulating the p66shc Signaling Pathway with Protocatechuic Acid Protects the Intestine from Ischemia-Reperfusion Injury and Alleviates Secondary Liver Damage. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1049420
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1049420
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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