Modulating the p66shc Signaling Pathway with Protocatechuic Acid Protects the Intestine from Ischemia-Reperfusion Injury and Alleviates Secondary Liver Damage
Joint Authors
Yao, Jihong
Ma, Lingfei
Wang, Guangzhi
Chen, Zhao
Li, Zhenlu
Zhao, Haidong
Wang, Shu
Ma, Zhenhai
Chang, Hong
Tian, Xiaofeng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Intestinal ischemia-reperfusion (I/R) injury is a serious clinical pathophysiological process that may result in acute local intestine and remote liver injury.
Protocatechuic acid (PCA), which has been widely studied as a polyphenolic compound, induces expression of antioxidative genes that combat oxidative stress and cell apoptosis.
In this study, we investigated the effect of PCA pretreatment for protecting intestinal I/R-induced local intestine and remote liver injury in mice.
Intestinal I/R was established by superior mesenteric artery occlusion for 45 min followed by reperfusion for 90 min.
After the reperfusion period, PCA pretreatment markedly alleviated intestine and liver injury induced by intestinal I/R as indicated by histological alterations, decreases in serological damage parameters and nuclear factor-kappa B and phospho-foxo3a protein expression levels, and increases in glutathione, glutathione peroxidase, manganese superoxide dismutase protein expression, and Bcl-xL protein expression in the intestine and liver.
These parameters were accompanied by PCA-induced adaptor protein p66shc suppression.
These results suggest that PCA has a significant protective effect in the intestine and liver following injury induced by intestinal I/R.
The protective effect of PCA may be attributed to the suppression of p66shc and the regulation of p66shc-related antioxidative and antiapoptotic factors.
American Psychological Association (APA)
Ma, Lingfei& Wang, Guangzhi& Chen, Zhao& Li, Zhenlu& Yao, Jihong& Zhao, Haidong…[et al.]. 2014. Modulating the p66shc Signaling Pathway with Protocatechuic Acid Protects the Intestine from Ischemia-Reperfusion Injury and Alleviates Secondary Liver Damage. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1049420
Modern Language Association (MLA)
Ma, Lingfei…[et al.]. Modulating the p66shc Signaling Pathway with Protocatechuic Acid Protects the Intestine from Ischemia-Reperfusion Injury and Alleviates Secondary Liver Damage. The Scientific World Journal No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1049420
American Medical Association (AMA)
Ma, Lingfei& Wang, Guangzhi& Chen, Zhao& Li, Zhenlu& Yao, Jihong& Zhao, Haidong…[et al.]. Modulating the p66shc Signaling Pathway with Protocatechuic Acid Protects the Intestine from Ischemia-Reperfusion Injury and Alleviates Secondary Liver Damage. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1049420
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049420