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Effects of L-Theanine on Posttraumatic Stress Disorder Induced Changes in Rat Brain Gene Expression
المؤلفون المشاركون
Ceremuga, Tomás Eduardo
Martinson, Stephanie
Washington, Jason
Revels, Robert
Wojcicki, Jessica
Crawford, Damali
Edwards, Robert
Kemper, Joshua Luke
Townsend, William Luke
Herron, Geno M.
Ceremuga, George Allen
Padron, Gina
Bentley, Michael
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Posttraumatic stress disorder (PTSD) is characterized by the occurrence of a traumatic event that is beyond the normal range of human experience.
The future of PTSD treatment may specifically target the molecular mechanisms of PTSD.
In the US, approximately 20% of adults report taking herbal products to treat medical illnesses.
L-theanine is the amino acid in green tea primarily responsible for relaxation effects.
No studies have evaluated the potential therapeutic properties of herbal medications on gene expression in PTSD.
We evaluated gene expression in PTSD-induced changes in the amygdala and hippocampus of Sprague-Dawley rats.
The rats were assigned to PTSD-stressed and nonstressed groups that received either saline, midazolam, L-theanine, or L-theanine + midazolam.
Amygdala and hippocampus tissue samples were analyzed for changes in gene expression.
One-way ANOVA was used to detect significant difference between groups in the amygdala and hippocampus.
Of 88 genes examined, 17 had a large effect size greater than 0.138.
Of these, 3 genes in the hippocampus and 5 genes in the amygdala were considered significant ( P < 0.05 ) between the groups.
RT-PCR analysis revealed significant changes between groups in several genes implicated in a variety of disorders ranging from PTSD, anxiety, mood disorders, and substance dependence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ceremuga, Tomás Eduardo& Martinson, Stephanie& Washington, Jason& Revels, Robert& Wojcicki, Jessica& Crawford, Damali…[et al.]. 2014. Effects of L-Theanine on Posttraumatic Stress Disorder Induced Changes in Rat Brain Gene Expression. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1049557
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ceremuga, Tomás Eduardo…[et al.]. Effects of L-Theanine on Posttraumatic Stress Disorder Induced Changes in Rat Brain Gene Expression. The Scientific World Journal No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1049557
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ceremuga, Tomás Eduardo& Martinson, Stephanie& Washington, Jason& Revels, Robert& Wojcicki, Jessica& Crawford, Damali…[et al.]. Effects of L-Theanine on Posttraumatic Stress Disorder Induced Changes in Rat Brain Gene Expression. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1049557
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1049557
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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