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Effects of L-Theanine on Posttraumatic Stress Disorder Induced Changes in Rat Brain Gene Expression
Joint Authors
Ceremuga, Tomás Eduardo
Martinson, Stephanie
Washington, Jason
Revels, Robert
Wojcicki, Jessica
Crawford, Damali
Edwards, Robert
Kemper, Joshua Luke
Townsend, William Luke
Herron, Geno M.
Ceremuga, George Allen
Padron, Gina
Bentley, Michael
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Posttraumatic stress disorder (PTSD) is characterized by the occurrence of a traumatic event that is beyond the normal range of human experience.
The future of PTSD treatment may specifically target the molecular mechanisms of PTSD.
In the US, approximately 20% of adults report taking herbal products to treat medical illnesses.
L-theanine is the amino acid in green tea primarily responsible for relaxation effects.
No studies have evaluated the potential therapeutic properties of herbal medications on gene expression in PTSD.
We evaluated gene expression in PTSD-induced changes in the amygdala and hippocampus of Sprague-Dawley rats.
The rats were assigned to PTSD-stressed and nonstressed groups that received either saline, midazolam, L-theanine, or L-theanine + midazolam.
Amygdala and hippocampus tissue samples were analyzed for changes in gene expression.
One-way ANOVA was used to detect significant difference between groups in the amygdala and hippocampus.
Of 88 genes examined, 17 had a large effect size greater than 0.138.
Of these, 3 genes in the hippocampus and 5 genes in the amygdala were considered significant ( P < 0.05 ) between the groups.
RT-PCR analysis revealed significant changes between groups in several genes implicated in a variety of disorders ranging from PTSD, anxiety, mood disorders, and substance dependence.
American Psychological Association (APA)
Ceremuga, Tomás Eduardo& Martinson, Stephanie& Washington, Jason& Revels, Robert& Wojcicki, Jessica& Crawford, Damali…[et al.]. 2014. Effects of L-Theanine on Posttraumatic Stress Disorder Induced Changes in Rat Brain Gene Expression. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1049557
Modern Language Association (MLA)
Ceremuga, Tomás Eduardo…[et al.]. Effects of L-Theanine on Posttraumatic Stress Disorder Induced Changes in Rat Brain Gene Expression. The Scientific World Journal No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1049557
American Medical Association (AMA)
Ceremuga, Tomás Eduardo& Martinson, Stephanie& Washington, Jason& Revels, Robert& Wojcicki, Jessica& Crawford, Damali…[et al.]. Effects of L-Theanine on Posttraumatic Stress Disorder Induced Changes in Rat Brain Gene Expression. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1049557
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049557