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Cholesterol-Lowering Potentials of Lactic Acid Bacteria Based on Bile-Salt Hydrolase Activity and Effect of Potent Strains on Cholesterol Metabolism In Vitro and In Vivo
المؤلفون المشاركون
Huang, Chun-Chi
Tsai, Cheng-Chih
Lin, Pei-Pei
Hsieh, You-Miin
Zhang, Zi-yi
Wu, Hui-Ching
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
This study collected different probiotic isolates from animal and plant sources to evaluate the bile-salt hydrolase activity of probiotics in vitro.
The deconjugation potential of bile acid was determined using high-performance liquid chromatography.
HepG2 cells were cultured with probiotic strains with high BSH activity.
The triglyceride (TG) and apolipoprotein B (apo B) secretion by HepG2 cells were evaluated.
Our results show that the BSH activity and bile-acid deconjugation abilities of Pediococcus acidilactici NBHK002, Bifidobacterium adolescentis NBHK006, Lactobacillus rhamnosus NBHK007, and Lactobacillus acidophilus NBHK008 were higher than those of the other probiotic strains.
The cholesterol concentration in cholesterol micelles was reduced within 24 h.
NBHK007 reduced the TG secretion by 100% after 48 h of incubation.
NBHK002, NBHK006, and NBHK007 could reduce apo B secretion by 33%, 38%, and 39%, respectively, after 24 h of incubation.
The product PROBIO S-23 produced a greater decrease in the total concentration of cholesterol, low-density lipoprotein, TG, and thiobarbituric acid reactive substance in the serum or livers of hamsters with hypercholesterolemia compared with that of hamsters fed with a high-fat and high-cholesterol diet.
These results show that the three probiotic strains of lactic acid bacteria are better candidates for reducing the risk of cardiovascular disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tsai, Cheng-Chih& Lin, Pei-Pei& Hsieh, You-Miin& Zhang, Zi-yi& Wu, Hui-Ching& Huang, Chun-Chi. 2014. Cholesterol-Lowering Potentials of Lactic Acid Bacteria Based on Bile-Salt Hydrolase Activity and Effect of Potent Strains on Cholesterol Metabolism In Vitro and In Vivo. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1050627
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tsai, Cheng-Chih…[et al.]. Cholesterol-Lowering Potentials of Lactic Acid Bacteria Based on Bile-Salt Hydrolase Activity and Effect of Potent Strains on Cholesterol Metabolism In Vitro and In Vivo. The Scientific World Journal No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1050627
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tsai, Cheng-Chih& Lin, Pei-Pei& Hsieh, You-Miin& Zhang, Zi-yi& Wu, Hui-Ching& Huang, Chun-Chi. Cholesterol-Lowering Potentials of Lactic Acid Bacteria Based on Bile-Salt Hydrolase Activity and Effect of Potent Strains on Cholesterol Metabolism In Vitro and In Vivo. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1050627
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1050627
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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