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Cholesterol-Lowering Potentials of Lactic Acid Bacteria Based on Bile-Salt Hydrolase Activity and Effect of Potent Strains on Cholesterol Metabolism In Vitro and In Vivo
Joint Authors
Huang, Chun-Chi
Tsai, Cheng-Chih
Lin, Pei-Pei
Hsieh, You-Miin
Zhang, Zi-yi
Wu, Hui-Ching
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
This study collected different probiotic isolates from animal and plant sources to evaluate the bile-salt hydrolase activity of probiotics in vitro.
The deconjugation potential of bile acid was determined using high-performance liquid chromatography.
HepG2 cells were cultured with probiotic strains with high BSH activity.
The triglyceride (TG) and apolipoprotein B (apo B) secretion by HepG2 cells were evaluated.
Our results show that the BSH activity and bile-acid deconjugation abilities of Pediococcus acidilactici NBHK002, Bifidobacterium adolescentis NBHK006, Lactobacillus rhamnosus NBHK007, and Lactobacillus acidophilus NBHK008 were higher than those of the other probiotic strains.
The cholesterol concentration in cholesterol micelles was reduced within 24 h.
NBHK007 reduced the TG secretion by 100% after 48 h of incubation.
NBHK002, NBHK006, and NBHK007 could reduce apo B secretion by 33%, 38%, and 39%, respectively, after 24 h of incubation.
The product PROBIO S-23 produced a greater decrease in the total concentration of cholesterol, low-density lipoprotein, TG, and thiobarbituric acid reactive substance in the serum or livers of hamsters with hypercholesterolemia compared with that of hamsters fed with a high-fat and high-cholesterol diet.
These results show that the three probiotic strains of lactic acid bacteria are better candidates for reducing the risk of cardiovascular disease.
American Psychological Association (APA)
Tsai, Cheng-Chih& Lin, Pei-Pei& Hsieh, You-Miin& Zhang, Zi-yi& Wu, Hui-Ching& Huang, Chun-Chi. 2014. Cholesterol-Lowering Potentials of Lactic Acid Bacteria Based on Bile-Salt Hydrolase Activity and Effect of Potent Strains on Cholesterol Metabolism In Vitro and In Vivo. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1050627
Modern Language Association (MLA)
Tsai, Cheng-Chih…[et al.]. Cholesterol-Lowering Potentials of Lactic Acid Bacteria Based on Bile-Salt Hydrolase Activity and Effect of Potent Strains on Cholesterol Metabolism In Vitro and In Vivo. The Scientific World Journal No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1050627
American Medical Association (AMA)
Tsai, Cheng-Chih& Lin, Pei-Pei& Hsieh, You-Miin& Zhang, Zi-yi& Wu, Hui-Ching& Huang, Chun-Chi. Cholesterol-Lowering Potentials of Lactic Acid Bacteria Based on Bile-Salt Hydrolase Activity and Effect of Potent Strains on Cholesterol Metabolism In Vitro and In Vivo. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1050627
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050627