Protective Effects of Trehalose on the Corneal Epithelial Cells
المؤلفون المشاركون
Aragona, Pasquale
Colosi, Pietro
Rania, Laura
Colosi, Francesca
Pisani, Antonina
Puzzolo, Domenico
Micali, Antonio
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Purpose.
Aim of the present work was to evaluate the effects of the trehalose on the corneal epithelium undergoing alcohol delamination.
Methods.
Twelve patients undergoing laser subepithelial keratomileusis (LASEK) were consecutively included in the study.
The right eyes were pretreated with 3% trehalose eye drops, whilst left eyes were used as control.
Epithelial specimens were processed for cells vitality assessment, apoptosis, and light and transmission electron microscopy; a morphometric analysis was performed in both groups.
Results.
In both trehalose-untreated eyes (TUE) and trehalose-treated eyes (TTE), the percentage of vital cells was similar and no apoptotic cells were observed.
In TUE, the corneal epithelium showed superficial cells with reduced microfolds, wing cells with vesicles and dilated intercellular spaces, and dark basal cells with vesicles and wide clefts.
In TTE, superficial and wing cells were better preserved, and basal cells were generally clear with intracytoplasmatic vesicles.
The morphometric analysis showed statistically significant differences between the two groups: the TTE epithelial height was higher, the basal cells showed larger area and clearer cytoplasm.
The distribution of desmosomes and hemidesmosomes was significantly different between the groups.
Conclusions.
Trehalose administration better preserved morphological and morphometric features of alcohol-treated corneal epithelium, when compared to controls.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aragona, Pasquale& Colosi, Pietro& Rania, Laura& Colosi, Francesca& Pisani, Antonina& Puzzolo, Domenico…[et al.]. 2014. Protective Effects of Trehalose on the Corneal Epithelial Cells. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050741
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aragona, Pasquale…[et al.]. Protective Effects of Trehalose on the Corneal Epithelial Cells. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1050741
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aragona, Pasquale& Colosi, Pietro& Rania, Laura& Colosi, Francesca& Pisani, Antonina& Puzzolo, Domenico…[et al.]. Protective Effects of Trehalose on the Corneal Epithelial Cells. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050741
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1050741
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر