Lung Matrix Metalloproteinase Activation following Partial Hepatic IschemiaReperfusion Injury in Rats
المؤلفون المشاركون
Freitas, Isabel
Perlini, Stefano
Ferrigno, Andrea
Bertone, Vittorio
Rizzo, Vittoria
Tarantola, Eleonora
Richelmi, Plinio
Vairetti, Mariapia
Palladini, Giuseppina
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Purpose.
Warm hepatic ischemia-reperfusion (I/R) injury can lead to multiorgan dysfunction.
The aim of the present study was to investigate whether acute liver I/R does affect the function and/or structure of remote organs such as lung, kidney, and heart via modulation of extracellular matrix remodelling.
Methods.
Male Sprague-Dawley rats were subjected to 30 min partial hepatic ischemia by clamping the hepatic artery and the portal vein.
After a 60 min reperfusion, liver, lung, kidney, and heart biopsies and blood samples were collected.
Serum hepatic enzymes, creatinine, urea, Troponin I and TNF-alpha, and tissue matrix metalloproteinases (MMP-2, MMP-9), myeloperoxidase (MPO), malondialdehyde (MDA), and morphology were monitored.
Results.
Serum levels of hepatic enzymes and TNF-alpha were concomitantly increased during hepatic I/R.
An increase in hepatic MMP-2 and MMP-9 activities was substantiated by tissue morphology alterations.
Notably, acute hepatic I/R affect the lung inasmuch as MMP-9 activity and MPO levels were increased.
No difference in MMPs and MPO was observed in kidney and heart.
Conclusions.
Although the underlying mechanism needs further investigation, this is the first study in which the MMP activation in a distant organ is reported; this event is probably TNF-alpha-mediated and the lung appears as the first remote organ to be involved in hepatic I/R injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Palladini, Giuseppina& Ferrigno, Andrea& Rizzo, Vittoria& Tarantola, Eleonora& Bertone, Vittorio& Freitas, Isabel…[et al.]. 2014. Lung Matrix Metalloproteinase Activation following Partial Hepatic IschemiaReperfusion Injury in Rats. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1051408
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Palladini, Giuseppina…[et al.]. Lung Matrix Metalloproteinase Activation following Partial Hepatic IschemiaReperfusion Injury in Rats. The Scientific World Journal No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1051408
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Palladini, Giuseppina& Ferrigno, Andrea& Rizzo, Vittoria& Tarantola, Eleonora& Bertone, Vittorio& Freitas, Isabel…[et al.]. Lung Matrix Metalloproteinase Activation following Partial Hepatic IschemiaReperfusion Injury in Rats. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1051408
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1051408
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر