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Lung Matrix Metalloproteinase Activation following Partial Hepatic IschemiaReperfusion Injury in Rats
Joint Authors
Freitas, Isabel
Perlini, Stefano
Ferrigno, Andrea
Bertone, Vittorio
Rizzo, Vittoria
Tarantola, Eleonora
Richelmi, Plinio
Vairetti, Mariapia
Palladini, Giuseppina
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Purpose.
Warm hepatic ischemia-reperfusion (I/R) injury can lead to multiorgan dysfunction.
The aim of the present study was to investigate whether acute liver I/R does affect the function and/or structure of remote organs such as lung, kidney, and heart via modulation of extracellular matrix remodelling.
Methods.
Male Sprague-Dawley rats were subjected to 30 min partial hepatic ischemia by clamping the hepatic artery and the portal vein.
After a 60 min reperfusion, liver, lung, kidney, and heart biopsies and blood samples were collected.
Serum hepatic enzymes, creatinine, urea, Troponin I and TNF-alpha, and tissue matrix metalloproteinases (MMP-2, MMP-9), myeloperoxidase (MPO), malondialdehyde (MDA), and morphology were monitored.
Results.
Serum levels of hepatic enzymes and TNF-alpha were concomitantly increased during hepatic I/R.
An increase in hepatic MMP-2 and MMP-9 activities was substantiated by tissue morphology alterations.
Notably, acute hepatic I/R affect the lung inasmuch as MMP-9 activity and MPO levels were increased.
No difference in MMPs and MPO was observed in kidney and heart.
Conclusions.
Although the underlying mechanism needs further investigation, this is the first study in which the MMP activation in a distant organ is reported; this event is probably TNF-alpha-mediated and the lung appears as the first remote organ to be involved in hepatic I/R injury.
American Psychological Association (APA)
Palladini, Giuseppina& Ferrigno, Andrea& Rizzo, Vittoria& Tarantola, Eleonora& Bertone, Vittorio& Freitas, Isabel…[et al.]. 2014. Lung Matrix Metalloproteinase Activation following Partial Hepatic IschemiaReperfusion Injury in Rats. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1051408
Modern Language Association (MLA)
Palladini, Giuseppina…[et al.]. Lung Matrix Metalloproteinase Activation following Partial Hepatic IschemiaReperfusion Injury in Rats. The Scientific World Journal No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1051408
American Medical Association (AMA)
Palladini, Giuseppina& Ferrigno, Andrea& Rizzo, Vittoria& Tarantola, Eleonora& Bertone, Vittorio& Freitas, Isabel…[et al.]. Lung Matrix Metalloproteinase Activation following Partial Hepatic IschemiaReperfusion Injury in Rats. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1051408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051408