A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs
المؤلفون المشاركون
Schaiquevich, Paula
Prados, Ana Paula
Kreil, Verónica
Monfrinotti, Agustina
Quaine, Pamela
Tarragona, Lisa
Hallu, Ruben
Rebuelto, Marcela
المصدر
Veterinary Medicine International
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
This study was conducted in order to characterize the pharmacokinetics of orally administered cephalexin to healthy adult and aged dogs, using a population pharmacokinetic approach.
Two hundred and eighty-six cephalexin plasma concentrations obtained from previous pharmacokinetic studies were used.
Sex, age, pharmaceutical formulation, and breed were evaluated as covariates.
A one-compartment model with an absorption lag-time (Tlag) best described the data.
The final model included age (adult; aged) on apparent volume of distribution (Vd/F), apparent elimination rate (ke/F), and Tlag; sex (female; male) on ke/F, and breed (Beagle; mixed-breed) on Vd/F.
Addition of the covariates to the model explained 78% of the interindividal variability (IIV) in Vd/F, 36% in ke/F, and 24% in Tlag, respectively.
Formulation did not affect the variability of any of the pharmacokinetic parameters.
Tlag was longer, whereas Vd/F and ke/F were lower in aged compared to adult animals; in female aged dogs ke/F was lower than in male aged dogs; however, the differences were of low magnitude.
Different disposition of cephalexin may be expected in aged dogs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Prados, Ana Paula& Schaiquevich, Paula& Kreil, Verónica& Monfrinotti, Agustina& Quaine, Pamela& Tarragona, Lisa…[et al.]. 2014. A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs. Veterinary Medicine International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051945
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Prados, Ana Paula…[et al.]. A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs. Veterinary Medicine International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1051945
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Prados, Ana Paula& Schaiquevich, Paula& Kreil, Verónica& Monfrinotti, Agustina& Quaine, Pamela& Tarragona, Lisa…[et al.]. A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs. Veterinary Medicine International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051945
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1051945
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر