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A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs
Joint Authors
Schaiquevich, Paula
Prados, Ana Paula
Kreil, Verónica
Monfrinotti, Agustina
Quaine, Pamela
Tarragona, Lisa
Hallu, Ruben
Rebuelto, Marcela
Source
Veterinary Medicine International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study was conducted in order to characterize the pharmacokinetics of orally administered cephalexin to healthy adult and aged dogs, using a population pharmacokinetic approach.
Two hundred and eighty-six cephalexin plasma concentrations obtained from previous pharmacokinetic studies were used.
Sex, age, pharmaceutical formulation, and breed were evaluated as covariates.
A one-compartment model with an absorption lag-time (Tlag) best described the data.
The final model included age (adult; aged) on apparent volume of distribution (Vd/F), apparent elimination rate (ke/F), and Tlag; sex (female; male) on ke/F, and breed (Beagle; mixed-breed) on Vd/F.
Addition of the covariates to the model explained 78% of the interindividal variability (IIV) in Vd/F, 36% in ke/F, and 24% in Tlag, respectively.
Formulation did not affect the variability of any of the pharmacokinetic parameters.
Tlag was longer, whereas Vd/F and ke/F were lower in aged compared to adult animals; in female aged dogs ke/F was lower than in male aged dogs; however, the differences were of low magnitude.
Different disposition of cephalexin may be expected in aged dogs.
American Psychological Association (APA)
Prados, Ana Paula& Schaiquevich, Paula& Kreil, Verónica& Monfrinotti, Agustina& Quaine, Pamela& Tarragona, Lisa…[et al.]. 2014. A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs. Veterinary Medicine International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051945
Modern Language Association (MLA)
Prados, Ana Paula…[et al.]. A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs. Veterinary Medicine International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1051945
American Medical Association (AMA)
Prados, Ana Paula& Schaiquevich, Paula& Kreil, Verónica& Monfrinotti, Agustina& Quaine, Pamela& Tarragona, Lisa…[et al.]. A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs. Veterinary Medicine International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051945
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051945