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Genetic Polymorphism and Expression of CXCR4 in Breast Cancer
المؤلفون المشاركون
Watanabe, Maria Angélica Ehara
Guembarovski, Alda Losi
Losi Guembarovski, Roberta
Ariza, Carolina Batista
de Almeida, Felipe Campos
Trugilo, Kleber Paiva
Jorge Sobrinho, Walter
Banin Hirata, Bruna Karina
Campos, Clodoaldo Zago
Oliveira, Carlos Eduardo Coral de
Okuyama Kishima, Marina
Freire Vitiello, Glauco Akelinghton
de Oliveira, Karen Brajão
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
CXCR4 genetic polymorphisms, as well as their expression level, have been associated with cancer development and prognosis.
The present study aimed to investigate the influence of CXCR4 rs2228014 polymorphism on its mRNA and protein expression in breast cancer samples.
It was observed that patients presented higher CXCR4 mRNA relative expression (5.7-fold) than normal mammary gland, but this expression was not correlated with patients clinicopathological features (nuclear grade, nodal status, ER status, PR status, p53 staining, Ki67 index, and HER-2 status).
Moreover, CXCR4 mRNA relative expression also did not differ regarding the presence or absence of T allele ( p = 0.301 ).
In the immunohistochemical assay, no difference was observed for CXCR4 cytoplasmic protein staining in relation to different genotypes ( p = 0.757 ); however, high cytoplasmic CXCR4 staining was verified in invasive breast carcinoma ( p < 0.01 ).
All in all, the results from present study indicated that rs2228014 genetic variant does not alter CXCR4 mRNA or protein expression.
However, this receptor was more expressed in tumor compared to normal tissue, in both RNA and protein levels, suggesting its promising applicability in the general context of mammary carcinogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Okuyama Kishima, Marina& de Oliveira, Karen Brajão& Ariza, Carolina Batista& Oliveira, Carlos Eduardo Coral de& Losi Guembarovski, Roberta& Banin Hirata, Bruna Karina…[et al.]. 2015. Genetic Polymorphism and Expression of CXCR4 in Breast Cancer. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052348
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Okuyama Kishima, Marina…[et al.]. Genetic Polymorphism and Expression of CXCR4 in Breast Cancer. Analytical Cellular Pathology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1052348
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Okuyama Kishima, Marina& de Oliveira, Karen Brajão& Ariza, Carolina Batista& Oliveira, Carlos Eduardo Coral de& Losi Guembarovski, Roberta& Banin Hirata, Bruna Karina…[et al.]. Genetic Polymorphism and Expression of CXCR4 in Breast Cancer. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052348
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1052348
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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