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Genetic Polymorphism and Expression of CXCR4 in Breast Cancer
Joint Authors
Watanabe, Maria Angélica Ehara
Guembarovski, Alda Losi
Losi Guembarovski, Roberta
Ariza, Carolina Batista
de Almeida, Felipe Campos
Trugilo, Kleber Paiva
Jorge Sobrinho, Walter
Banin Hirata, Bruna Karina
Campos, Clodoaldo Zago
Oliveira, Carlos Eduardo Coral de
Okuyama Kishima, Marina
Freire Vitiello, Glauco Akelinghton
de Oliveira, Karen Brajão
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
CXCR4 genetic polymorphisms, as well as their expression level, have been associated with cancer development and prognosis.
The present study aimed to investigate the influence of CXCR4 rs2228014 polymorphism on its mRNA and protein expression in breast cancer samples.
It was observed that patients presented higher CXCR4 mRNA relative expression (5.7-fold) than normal mammary gland, but this expression was not correlated with patients clinicopathological features (nuclear grade, nodal status, ER status, PR status, p53 staining, Ki67 index, and HER-2 status).
Moreover, CXCR4 mRNA relative expression also did not differ regarding the presence or absence of T allele ( p = 0.301 ).
In the immunohistochemical assay, no difference was observed for CXCR4 cytoplasmic protein staining in relation to different genotypes ( p = 0.757 ); however, high cytoplasmic CXCR4 staining was verified in invasive breast carcinoma ( p < 0.01 ).
All in all, the results from present study indicated that rs2228014 genetic variant does not alter CXCR4 mRNA or protein expression.
However, this receptor was more expressed in tumor compared to normal tissue, in both RNA and protein levels, suggesting its promising applicability in the general context of mammary carcinogenesis.
American Psychological Association (APA)
Okuyama Kishima, Marina& de Oliveira, Karen Brajão& Ariza, Carolina Batista& Oliveira, Carlos Eduardo Coral de& Losi Guembarovski, Roberta& Banin Hirata, Bruna Karina…[et al.]. 2015. Genetic Polymorphism and Expression of CXCR4 in Breast Cancer. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052348
Modern Language Association (MLA)
Okuyama Kishima, Marina…[et al.]. Genetic Polymorphism and Expression of CXCR4 in Breast Cancer. Analytical Cellular Pathology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1052348
American Medical Association (AMA)
Okuyama Kishima, Marina& de Oliveira, Karen Brajão& Ariza, Carolina Batista& Oliveira, Carlos Eduardo Coral de& Losi Guembarovski, Roberta& Banin Hirata, Bruna Karina…[et al.]. Genetic Polymorphism and Expression of CXCR4 in Breast Cancer. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052348
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052348