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Diphenyl Ditelluride Intoxication Triggers Histological Changes in Liver, Kidney, and Lung of Mice
المؤلفون المشاركون
Vargas Barbosa, Nilda
da Rocha, João Batista Teixeira
Luz, Sônia Cristina Almeida
Daubermann, Melissa Falster
Thomé, Gustavo Roberto
dos Santos, Matheus Mülling
Ramos, Angelica
Torres Salazar, Gerson
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Tellurium compounds may be cytotoxic to different cells types.
Thus, this work evaluated the effect of diphenyl ditelluride ((PhTe)2), an organotellurium commonly used in organic synthesis, on the morphology of liver, kidney, and lung.
Adult mice were acutely (a subcutaneous single dose: 250 μmol/kg) or subchronically (one daily subcutaneous dose: 10 or 50 μmol/kg for 7 and 14 days) exposed to (PhTe)2.
Afterwards, the histological analyses of liver, kidney, and lungs were performed.
Liver histology revealed that the hepatocytes of mice subchronically exposed to (PhTe)2 presented cytoplasmic vacuolization, hydropic degeneration, and hyperchromatic nuclei.
Subchronic exposure to 50 μmol/kg (PhTe)2 also caused hepatic necrosis.
Microvesicular and macrovesicular steatosis were identified in liver of mice acutely exposed to (PhTe)2.
Acute and subchronic intoxication with (PhTe)2 induced changes on epithelial cells of renal tubules, namely, loss of brush border and cytoplasmatic vacuolization.
Atrophy and hypertrophy, cast proteinaceous formation, and acute tubular necrosis were also identified in renal tissue.
Mice subchronically exposed to 50 μmol/kg (PhTe)2 developed intra-alveolar edema and alveolar wall congestion in some areas of lungs.
Acute exposure to (PhTe)2 did not cause histological changes in lungs.
Our data show that (PhTe)2 may be considered a histotoxic agent for liver, kidney, and lung.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Luz, Sônia Cristina Almeida& Daubermann, Melissa Falster& Thomé, Gustavo Roberto& dos Santos, Matheus Mülling& Ramos, Angelica& Torres Salazar, Gerson…[et al.]. 2015. Diphenyl Ditelluride Intoxication Triggers Histological Changes in Liver, Kidney, and Lung of Mice. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1052369
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Luz, Sônia Cristina Almeida…[et al.]. Diphenyl Ditelluride Intoxication Triggers Histological Changes in Liver, Kidney, and Lung of Mice. Analytical Cellular Pathology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1052369
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Luz, Sônia Cristina Almeida& Daubermann, Melissa Falster& Thomé, Gustavo Roberto& dos Santos, Matheus Mülling& Ramos, Angelica& Torres Salazar, Gerson…[et al.]. Diphenyl Ditelluride Intoxication Triggers Histological Changes in Liver, Kidney, and Lung of Mice. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1052369
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1052369
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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