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Diphenyl Ditelluride Intoxication Triggers Histological Changes in Liver, Kidney, and Lung of Mice
Joint Authors
Vargas Barbosa, Nilda
da Rocha, João Batista Teixeira
Luz, Sônia Cristina Almeida
Daubermann, Melissa Falster
Thomé, Gustavo Roberto
dos Santos, Matheus Mülling
Ramos, Angelica
Torres Salazar, Gerson
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Tellurium compounds may be cytotoxic to different cells types.
Thus, this work evaluated the effect of diphenyl ditelluride ((PhTe)2), an organotellurium commonly used in organic synthesis, on the morphology of liver, kidney, and lung.
Adult mice were acutely (a subcutaneous single dose: 250 μmol/kg) or subchronically (one daily subcutaneous dose: 10 or 50 μmol/kg for 7 and 14 days) exposed to (PhTe)2.
Afterwards, the histological analyses of liver, kidney, and lungs were performed.
Liver histology revealed that the hepatocytes of mice subchronically exposed to (PhTe)2 presented cytoplasmic vacuolization, hydropic degeneration, and hyperchromatic nuclei.
Subchronic exposure to 50 μmol/kg (PhTe)2 also caused hepatic necrosis.
Microvesicular and macrovesicular steatosis were identified in liver of mice acutely exposed to (PhTe)2.
Acute and subchronic intoxication with (PhTe)2 induced changes on epithelial cells of renal tubules, namely, loss of brush border and cytoplasmatic vacuolization.
Atrophy and hypertrophy, cast proteinaceous formation, and acute tubular necrosis were also identified in renal tissue.
Mice subchronically exposed to 50 μmol/kg (PhTe)2 developed intra-alveolar edema and alveolar wall congestion in some areas of lungs.
Acute exposure to (PhTe)2 did not cause histological changes in lungs.
Our data show that (PhTe)2 may be considered a histotoxic agent for liver, kidney, and lung.
American Psychological Association (APA)
Luz, Sônia Cristina Almeida& Daubermann, Melissa Falster& Thomé, Gustavo Roberto& dos Santos, Matheus Mülling& Ramos, Angelica& Torres Salazar, Gerson…[et al.]. 2015. Diphenyl Ditelluride Intoxication Triggers Histological Changes in Liver, Kidney, and Lung of Mice. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1052369
Modern Language Association (MLA)
Luz, Sônia Cristina Almeida…[et al.]. Diphenyl Ditelluride Intoxication Triggers Histological Changes in Liver, Kidney, and Lung of Mice. Analytical Cellular Pathology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1052369
American Medical Association (AMA)
Luz, Sônia Cristina Almeida& Daubermann, Melissa Falster& Thomé, Gustavo Roberto& dos Santos, Matheus Mülling& Ramos, Angelica& Torres Salazar, Gerson…[et al.]. Diphenyl Ditelluride Intoxication Triggers Histological Changes in Liver, Kidney, and Lung of Mice. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1052369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052369