Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice

المؤلفون المشاركون

Jimenez, Rachel V.
Morgan, Todd E.
Bali, Namrata
Hou, Xiaogang
Finch, Caleb E.
McCrory, Mark A.
Szalai, Alexander J.
Wright, Tyler T.

المصدر

Autoimmune Diseases

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-09-03

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأمراض

الملخص EN

We recently demonstrated that human C-reactive protein (CRP), expressed hepatically in transgenic mice (CRPtg), improved the outcome of experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS).

The liver is the primary site of CRP synthesis in humans and in CRPtg mice but is also expressed by both at low levels in the CNS.

To determine if CNS expression of human CRP is sufficient to impact EAE, we generated neuronal CRP transgenic mice (nCRPtg) wherein human CRP expression is driven by the neuron-specific Ca2+/calmodulin-dependent protein kinase IIα (CaMKIIα) gene promoter.

We found that hepatically expressed/blood-borne CRP, but not CNS expressed CRP, lessened EAE severity.

These outcomes indicate that the protective actions of human CRP in EAE are manifested in the periphery and not in the CNS and reveal a previously unappreciated site specificity for the beneficial actions of CRP in CNS disease.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wright, Tyler T.& Jimenez, Rachel V.& Morgan, Todd E.& Bali, Namrata& Hou, Xiaogang& McCrory, Mark A.…[et al.]. 2015. Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice. Autoimmune Diseases،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052389

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wright, Tyler T.…[et al.]. Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice. Autoimmune Diseases No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1052389

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wright, Tyler T.& Jimenez, Rachel V.& Morgan, Todd E.& Bali, Namrata& Hou, Xiaogang& McCrory, Mark A.…[et al.]. Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice. Autoimmune Diseases. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052389

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1052389