Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice
Joint Authors
Jimenez, Rachel V.
Morgan, Todd E.
Bali, Namrata
Hou, Xiaogang
Finch, Caleb E.
McCrory, Mark A.
Szalai, Alexander J.
Wright, Tyler T.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We recently demonstrated that human C-reactive protein (CRP), expressed hepatically in transgenic mice (CRPtg), improved the outcome of experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS).
The liver is the primary site of CRP synthesis in humans and in CRPtg mice but is also expressed by both at low levels in the CNS.
To determine if CNS expression of human CRP is sufficient to impact EAE, we generated neuronal CRP transgenic mice (nCRPtg) wherein human CRP expression is driven by the neuron-specific Ca2+/calmodulin-dependent protein kinase IIα (CaMKIIα) gene promoter.
We found that hepatically expressed/blood-borne CRP, but not CNS expressed CRP, lessened EAE severity.
These outcomes indicate that the protective actions of human CRP in EAE are manifested in the periphery and not in the CNS and reveal a previously unappreciated site specificity for the beneficial actions of CRP in CNS disease.
American Psychological Association (APA)
Wright, Tyler T.& Jimenez, Rachel V.& Morgan, Todd E.& Bali, Namrata& Hou, Xiaogang& McCrory, Mark A.…[et al.]. 2015. Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice. Autoimmune Diseases،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052389
Modern Language Association (MLA)
Wright, Tyler T.…[et al.]. Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice. Autoimmune Diseases No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1052389
American Medical Association (AMA)
Wright, Tyler T.& Jimenez, Rachel V.& Morgan, Todd E.& Bali, Namrata& Hou, Xiaogang& McCrory, Mark A.…[et al.]. Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice. Autoimmune Diseases. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052389