Therapeutic Effect of Saponin Rich Fraction of Achyranthes aspera Linn. on Adjuvant-Induced Arthritis in Sprague-Dawley Rats

المؤلفون المشاركون

Kothavade, Pankaj S.
Nagmoti, Dnyaneshwar M.
Bulani, Vipin D.
Deshpande, Padmini S.
Gawali, Nitin B.
Juvekar, Archana R.

المصدر

Autoimmune Diseases

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-07-26

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأمراض

الملخص EN

Objective.

Achyranthes aspera Linn.

(AA) is used in folklore for the treatment of various inflammatory ailments and arthritis like conditions.

Anti-inflammatory activity of saponin rich (SR) fraction of AA has been previously reported.

The objective of this study was to assess the antiarthritic effect of SR fraction of Achyranthes aspera in adjuvant-induced arthritic rats.

Methods.

Arthritis was assessed by arthritis score, paw volume, changes in tibiotarsal joint thickness, hyperalgesic parameters, and spleen and thymus index.

Haematological, serum, biochemical, and inflammatory cytokine and in vivo antioxidant parameters were measured on the last day of the study.

Results.

SR fraction significantly suppressed paw swelling and arthritic score and improved the pain threshold in motility and stair climbing tests.

There was a reversal in the levels of altered parameters, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and antioxidant parameters like superoxide dismutase, catalase, glutathione, malondialdehyde, and nitric oxide.

SR fraction significantly decreased plasma levels of tumor necrosis factor-alpha and interleukin-6.

Moreover, histopathology revealed a significant reduction in synovial hyperplasia, inflammatory cell infiltration, and bone destruction in the joints.

Conclusion.

These observations explain the therapeutic benefit of SR fraction of AA in suppressing the progression of adjuvant-induced arthritis in rats.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kothavade, Pankaj S.& Bulani, Vipin D.& Nagmoti, Dnyaneshwar M.& Deshpande, Padmini S.& Gawali, Nitin B.& Juvekar, Archana R.. 2015. Therapeutic Effect of Saponin Rich Fraction of Achyranthes aspera Linn. on Adjuvant-Induced Arthritis in Sprague-Dawley Rats. Autoimmune Diseases،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052393

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Bulani, Vipin D.…[et al.]. Therapeutic Effect of Saponin Rich Fraction of Achyranthes aspera Linn. on Adjuvant-Induced Arthritis in Sprague-Dawley Rats. Autoimmune Diseases No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1052393

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kothavade, Pankaj S.& Bulani, Vipin D.& Nagmoti, Dnyaneshwar M.& Deshpande, Padmini S.& Gawali, Nitin B.& Juvekar, Archana R.. Therapeutic Effect of Saponin Rich Fraction of Achyranthes aspera Linn. on Adjuvant-Induced Arthritis in Sprague-Dawley Rats. Autoimmune Diseases. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052393

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1052393