Therapeutic Effect of Saponin Rich Fraction of Achyranthes aspera Linn. on Adjuvant-Induced Arthritis in Sprague-Dawley Rats
Joint Authors
Kothavade, Pankaj S.
Nagmoti, Dnyaneshwar M.
Bulani, Vipin D.
Deshpande, Padmini S.
Gawali, Nitin B.
Juvekar, Archana R.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Achyranthes aspera Linn.
(AA) is used in folklore for the treatment of various inflammatory ailments and arthritis like conditions.
Anti-inflammatory activity of saponin rich (SR) fraction of AA has been previously reported.
The objective of this study was to assess the antiarthritic effect of SR fraction of Achyranthes aspera in adjuvant-induced arthritic rats.
Methods.
Arthritis was assessed by arthritis score, paw volume, changes in tibiotarsal joint thickness, hyperalgesic parameters, and spleen and thymus index.
Haematological, serum, biochemical, and inflammatory cytokine and in vivo antioxidant parameters were measured on the last day of the study.
Results.
SR fraction significantly suppressed paw swelling and arthritic score and improved the pain threshold in motility and stair climbing tests.
There was a reversal in the levels of altered parameters, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and antioxidant parameters like superoxide dismutase, catalase, glutathione, malondialdehyde, and nitric oxide.
SR fraction significantly decreased plasma levels of tumor necrosis factor-alpha and interleukin-6.
Moreover, histopathology revealed a significant reduction in synovial hyperplasia, inflammatory cell infiltration, and bone destruction in the joints.
Conclusion.
These observations explain the therapeutic benefit of SR fraction of AA in suppressing the progression of adjuvant-induced arthritis in rats.
American Psychological Association (APA)
Kothavade, Pankaj S.& Bulani, Vipin D.& Nagmoti, Dnyaneshwar M.& Deshpande, Padmini S.& Gawali, Nitin B.& Juvekar, Archana R.. 2015. Therapeutic Effect of Saponin Rich Fraction of Achyranthes aspera Linn. on Adjuvant-Induced Arthritis in Sprague-Dawley Rats. Autoimmune Diseases،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052393
Modern Language Association (MLA)
Bulani, Vipin D.…[et al.]. Therapeutic Effect of Saponin Rich Fraction of Achyranthes aspera Linn. on Adjuvant-Induced Arthritis in Sprague-Dawley Rats. Autoimmune Diseases No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1052393
American Medical Association (AMA)
Kothavade, Pankaj S.& Bulani, Vipin D.& Nagmoti, Dnyaneshwar M.& Deshpande, Padmini S.& Gawali, Nitin B.& Juvekar, Archana R.. Therapeutic Effect of Saponin Rich Fraction of Achyranthes aspera Linn. on Adjuvant-Induced Arthritis in Sprague-Dawley Rats. Autoimmune Diseases. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052393