Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery
المؤلفون المشاركون
Tran, Toan
Hernandez, Mariana
Patel, Dhruvil
Wu, Ji
المصدر
Advances in Materials Science and Engineering
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-29
دولة النشر
مصر
عدد الصفحات
6
الملخص EN
Electrospun microfibers (MFs) composed of pH and temperature responsive polymers can be used for controllable and variable delivery of ibuprofen.
First, electrospinning technique was employed to prepare poly(ε-caprolactone) (PCL) and poly(N-isopropylacrylamide-co-methacrylic acid) (pNIPAM-co-MAA) MFs containing ibuprofen.
It was found that drug release rates from PCL MFs cannot be significantly varied by either temperature (22–40°C) or pH values (1.7–7.4).
In contrast, the ibuprofen (IP) diffusion rates from pNIPAM-co-MAA MFs were very sensitive to changes in both temperature and pH.
The IP release from pNIPAM-co-MAA MFs was highly linear and controllable when the temperature was above the lower critical solution temperature (LCST) of pNIPAM-co-MAA (33°C) and the pH was lower than the pKa of carboxylic acids (pH 2).
At room temperature, however, the release rate was dramatically increased by nearly ten times compared to that at higher temperature and lower pH.
Such a unique and controllable drug delivery system could be naturally envisioned to find many practical applications in biomedical and pharmaceutical sciences such as programmable transdermal drug delivery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tran, Toan& Hernandez, Mariana& Patel, Dhruvil& Wu, Ji. 2015. Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery. Advances in Materials Science and Engineering،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053106
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tran, Toan…[et al.]. Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery. Advances in Materials Science and Engineering No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1053106
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tran, Toan& Hernandez, Mariana& Patel, Dhruvil& Wu, Ji. Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery. Advances in Materials Science and Engineering. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053106
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1053106
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر