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Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery
Joint Authors
Tran, Toan
Hernandez, Mariana
Patel, Dhruvil
Wu, Ji
Source
Advances in Materials Science and Engineering
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-29
Country of Publication
Egypt
No. of Pages
6
Abstract EN
Electrospun microfibers (MFs) composed of pH and temperature responsive polymers can be used for controllable and variable delivery of ibuprofen.
First, electrospinning technique was employed to prepare poly(ε-caprolactone) (PCL) and poly(N-isopropylacrylamide-co-methacrylic acid) (pNIPAM-co-MAA) MFs containing ibuprofen.
It was found that drug release rates from PCL MFs cannot be significantly varied by either temperature (22–40°C) or pH values (1.7–7.4).
In contrast, the ibuprofen (IP) diffusion rates from pNIPAM-co-MAA MFs were very sensitive to changes in both temperature and pH.
The IP release from pNIPAM-co-MAA MFs was highly linear and controllable when the temperature was above the lower critical solution temperature (LCST) of pNIPAM-co-MAA (33°C) and the pH was lower than the pKa of carboxylic acids (pH 2).
At room temperature, however, the release rate was dramatically increased by nearly ten times compared to that at higher temperature and lower pH.
Such a unique and controllable drug delivery system could be naturally envisioned to find many practical applications in biomedical and pharmaceutical sciences such as programmable transdermal drug delivery.
American Psychological Association (APA)
Tran, Toan& Hernandez, Mariana& Patel, Dhruvil& Wu, Ji. 2015. Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery. Advances in Materials Science and Engineering،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053106
Modern Language Association (MLA)
Tran, Toan…[et al.]. Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery. Advances in Materials Science and Engineering No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1053106
American Medical Association (AMA)
Tran, Toan& Hernandez, Mariana& Patel, Dhruvil& Wu, Ji. Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery. Advances in Materials Science and Engineering. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1053106