Effect of Simvastatin on Arterial Stiffness in Patients with Statin Myalgia
المؤلفون المشاركون
Lorson, Lindsay
White, C. Michael
Thompson, Paul D.
Ballard, Kevin D.
Parker, Beth A.
المصدر
Advances in Preventive Medicine
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-15
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Statins reduce arterial stiffness but are also associated with mild muscle complaints.
It is unclear whether individuals with muscle symptoms experience the same vascular benefit or whether statins affect striated and smooth muscle cells differently.
We examined the effect of simvastatin treatment on arterial stiffness in patients who did versus those who did not exhibit muscle symptoms.
Patients with a history of statin-related muscle complaints (n=115) completed an 8 wk randomized, double-blind, cross-over trial of daily simvastatin 20 mg and placebo.
Serum lipids and pulse wave velocity (PWV) were assessed before and after each treatment.
Muscle symptoms with daily simvastatin treatment were reported by 38 patients (33%).
Compared to baseline, central PWV decreased (P=0.01) following simvastatin treatment but not placebo (drug ∗ time interaction: P=0.047).
Changes in central PWV with simvastatin treatment were not influenced by myalgia status or time on simvastatin (P≥0.15).
Change in central PWV after simvastatin treatment was inversely correlated with age (r=-0.207, P=0.030), suggesting that advancing age is associated with enhanced statin-mediated arterial destiffening.
In patients with a history of statin-related muscle complaints, the development of myalgia with short-term simvastatin treatment did not attenuate the improvement in arterial stiffness.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ballard, Kevin D.& Lorson, Lindsay& White, C. Michael& Thompson, Paul D.& Parker, Beth A.. 2015. Effect of Simvastatin on Arterial Stiffness in Patients with Statin Myalgia. Advances in Preventive Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053876
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ballard, Kevin D.…[et al.]. Effect of Simvastatin on Arterial Stiffness in Patients with Statin Myalgia. Advances in Preventive Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1053876
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ballard, Kevin D.& Lorson, Lindsay& White, C. Michael& Thompson, Paul D.& Parker, Beth A.. Effect of Simvastatin on Arterial Stiffness in Patients with Statin Myalgia. Advances in Preventive Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053876
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1053876
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر