Effect of Simvastatin on Arterial Stiffness in Patients with Statin Myalgia
Joint Authors
Lorson, Lindsay
White, C. Michael
Thompson, Paul D.
Ballard, Kevin D.
Parker, Beth A.
Source
Advances in Preventive Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Statins reduce arterial stiffness but are also associated with mild muscle complaints.
It is unclear whether individuals with muscle symptoms experience the same vascular benefit or whether statins affect striated and smooth muscle cells differently.
We examined the effect of simvastatin treatment on arterial stiffness in patients who did versus those who did not exhibit muscle symptoms.
Patients with a history of statin-related muscle complaints (n=115) completed an 8 wk randomized, double-blind, cross-over trial of daily simvastatin 20 mg and placebo.
Serum lipids and pulse wave velocity (PWV) were assessed before and after each treatment.
Muscle symptoms with daily simvastatin treatment were reported by 38 patients (33%).
Compared to baseline, central PWV decreased (P=0.01) following simvastatin treatment but not placebo (drug ∗ time interaction: P=0.047).
Changes in central PWV with simvastatin treatment were not influenced by myalgia status or time on simvastatin (P≥0.15).
Change in central PWV after simvastatin treatment was inversely correlated with age (r=-0.207, P=0.030), suggesting that advancing age is associated with enhanced statin-mediated arterial destiffening.
In patients with a history of statin-related muscle complaints, the development of myalgia with short-term simvastatin treatment did not attenuate the improvement in arterial stiffness.
American Psychological Association (APA)
Ballard, Kevin D.& Lorson, Lindsay& White, C. Michael& Thompson, Paul D.& Parker, Beth A.. 2015. Effect of Simvastatin on Arterial Stiffness in Patients with Statin Myalgia. Advances in Preventive Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053876
Modern Language Association (MLA)
Ballard, Kevin D.…[et al.]. Effect of Simvastatin on Arterial Stiffness in Patients with Statin Myalgia. Advances in Preventive Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1053876
American Medical Association (AMA)
Ballard, Kevin D.& Lorson, Lindsay& White, C. Michael& Thompson, Paul D.& Parker, Beth A.. Effect of Simvastatin on Arterial Stiffness in Patients with Statin Myalgia. Advances in Preventive Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053876
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1053876