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Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study
المؤلفون المشاركون
Gupta, Gaurav
Jia Jia, Tay
Yee Woon, Lim
Kumar Chellappan, Dinesh
Candasamy, Mayuren
Dua, Kamal
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-22
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The present study was designed to evaluate the acute and chronic antidepressant effect of genistein in combination with amitriptyline in mice.
Animals were divided into six groups (n=6) for treatment with water, genistein, or amitriptyline, either alone or in combination for ten days.
Animals were subjected to locomotor activity testing; tail suspension test (TST); and forced swim test (FST) and immobility time was recorded on day one and day ten.
Acute treatment of all treatment groups did not significantly reduce the immobility time (p>0.05).
Chronic treatment of combination of genistein (10 mg/kg) and amitriptyline (5 mg/kg and 10 mg/kg) significantly reduced the immobility time as compared to control group (p<0.001) and was comparable to amitriptyline alone (10 mg/kg).
However, no changes in anti-immobility activity in combination of subeffective doses of genistein (5 mg/kg) and amitriptyline (5 mg/kg) were observed.
Genistein at its standard dose (10 mg/kg) rendered synergistic effects in combination with subeffective dose of amitriptyline (5 mg/kg) and additive effects in combination with therapeutic dose of amitriptyline (10 mg/kg).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gupta, Gaurav& Jia Jia, Tay& Yee Woon, Lim& Kumar Chellappan, Dinesh& Candasamy, Mayuren& Dua, Kamal. 2015. Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053898
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gupta, Gaurav…[et al.]. Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study. Advances in Pharmacological and Pharmaceutical Sciences No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1053898
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gupta, Gaurav& Jia Jia, Tay& Yee Woon, Lim& Kumar Chellappan, Dinesh& Candasamy, Mayuren& Dua, Kamal. Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study. Advances in Pharmacological and Pharmaceutical Sciences. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053898
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1053898
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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