Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study
Joint Authors
Gupta, Gaurav
Jia Jia, Tay
Yee Woon, Lim
Kumar Chellappan, Dinesh
Candasamy, Mayuren
Dua, Kamal
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The present study was designed to evaluate the acute and chronic antidepressant effect of genistein in combination with amitriptyline in mice.
Animals were divided into six groups (n=6) for treatment with water, genistein, or amitriptyline, either alone or in combination for ten days.
Animals were subjected to locomotor activity testing; tail suspension test (TST); and forced swim test (FST) and immobility time was recorded on day one and day ten.
Acute treatment of all treatment groups did not significantly reduce the immobility time (p>0.05).
Chronic treatment of combination of genistein (10 mg/kg) and amitriptyline (5 mg/kg and 10 mg/kg) significantly reduced the immobility time as compared to control group (p<0.001) and was comparable to amitriptyline alone (10 mg/kg).
However, no changes in anti-immobility activity in combination of subeffective doses of genistein (5 mg/kg) and amitriptyline (5 mg/kg) were observed.
Genistein at its standard dose (10 mg/kg) rendered synergistic effects in combination with subeffective dose of amitriptyline (5 mg/kg) and additive effects in combination with therapeutic dose of amitriptyline (10 mg/kg).
American Psychological Association (APA)
Gupta, Gaurav& Jia Jia, Tay& Yee Woon, Lim& Kumar Chellappan, Dinesh& Candasamy, Mayuren& Dua, Kamal. 2015. Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053898
Modern Language Association (MLA)
Gupta, Gaurav…[et al.]. Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study. Advances in Pharmacological and Pharmaceutical Sciences No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1053898
American Medical Association (AMA)
Gupta, Gaurav& Jia Jia, Tay& Yee Woon, Lim& Kumar Chellappan, Dinesh& Candasamy, Mayuren& Dua, Kamal. Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study. Advances in Pharmacological and Pharmaceutical Sciences. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1053898
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1053898